Yup. Looks like you can atone for original antigenic sin. As with all learning, repetition is key 🥲 (The sky ain’t falling. Imprinting is real, but reports of the immune system’s demise were premature.) h/t @thelonevirologist.bsky.social #Virology #VaccinesWork #Omicron #Covid19 #science https://www.nature.com/articles/s41586-023-06753-7
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting - Nature
Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multiple updated boosters.Nature