The APOBEC3B cytidine deaminase is an adenovirus restriction factor
"we show that adenovirus infection leads to a reduction of the quantity and/or enzymatic activity of the APOBEC3B protein depending on the strains. The A12 strain seems less able to resist APOBEC3B than the B3 or C2 strains, a characteristic which could explain the strong depletion of the APOBEC3-targeted motifs in the A12 genome."
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011156
#viruses #virology
"we show that adenovirus infection leads to a reduction of the quantity and/or enzymatic activity of the APOBEC3B protein depending on the strains. The A12 strain seems less able to resist APOBEC3B than the B3 or C2 strains, a characteristic which could explain the strong depletion of the APOBEC3-targeted motifs in the A12 genome."
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011156
#viruses #virology
The APOBEC3B cytidine deaminase is an adenovirus restriction factor
Author summary The APOBEC3B protein is overexpressed in many human tumors and promotes genetic diversity and resistance to drug and oncolytic viruses.journals.plos.org