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Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage

https://www.nature.com/articles/s41587-025-02570-7

#phages #viruses


Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage - Nature Biotechnology

Biologics are delivered to the gut using phage that infects resident commensal bacteria.
Nature
#viruses #Phages
in reply to Frank Aylward

Marcia MacDonald
Marcia MacDonald
• •
If I still worked in anti-doping science this technology would probably be very concerning.
This entry was edited (1 month ago)
in reply to Frank Aylward

Marcia MacDonald
Marcia MacDonald
• •
I wasn't referring to performance enhancement specifically, but that production of (homologous) proteins is hard to detect. Maybe the T4 would have an engineered sequence that could be detected, or possibly the protein would be different enough from the endogenous version (e.g. different glycosylation like is used to detect EPO), but those testing methods are expensive.

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