"Here, we identified an endogenous cGAS-like enzyme in Pseudomonas aeruginosa that generates 3′,3′-cGAMP during phage infection, signals to a phospholipase effector, and limits phage replication."
#Microbiology #InnateImmunity
https://www.cell.com/cell/fulltext/S0092-8674(22)01584-7
#Microbiology #InnateImmunity
https://www.cell.com/cell/fulltext/S0092-8674(22)01584-7
Bacteriophages inhibit and evade cGAS-like immune function in bacteria
Bacteriophages antagonize cGAS-like bacterial immunity by sequestering immune signaling molecules and acquiring capsid gene mutations.Cell