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Items tagged with: innateimmunity
An antibacterial peptide encoded in the mitochondrial genome (#preprint).
#immunology #InnateImmunity
"We demonstrate that MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c) is a mitochondrial-encoded amphipathic and cationic peptide with direct antibacterial and immunomodulatory functions, consistent with the peptide chemistry and functions of known HDPs."
https://www.biorxiv.org/content/10.1101/2023.03.02.530691v1
#immunology #InnateImmunity
"We demonstrate that MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c) is a mitochondrial-encoded amphipathic and cationic peptide with direct antibacterial and immunomodulatory functions, consistent with the peptide chemistry and functions of known HDPs."
https://www.biorxiv.org/content/10.1101/2023.03.02.530691v1
The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide
The mitochondrial DNA (mtDNA) can trigger immune responses and directly entrap pathogens, but it is not known to encode for active immune factors. The immune system is traditionally thought to be exclusively nuclear-encoded.bioRxiv
"Here, we identified an endogenous cGAS-like enzyme in Pseudomonas aeruginosa that generates 3′,3′-cGAMP during phage infection, signals to a phospholipase effector, and limits phage replication."
#Microbiology #InnateImmunity
https://www.cell.com/cell/fulltext/S0092-8674(22)01584-7
#Microbiology #InnateImmunity
https://www.cell.com/cell/fulltext/S0092-8674(22)01584-7
Bacteriophages inhibit and evade cGAS-like immune function in bacteria
Bacteriophages antagonize cGAS-like bacterial immunity by sequestering immune signaling molecules and acquiring capsid gene mutations.Cell