Phylodynamics of deer tick virus in North America
https://academic.oup.com/ve/advance-article/doi/10.1093/ve/vead008/7008731?rss=1
#viruses #virology
https://academic.oup.com/ve/advance-article/doi/10.1093/ve/vead008/7008731?rss=1
#viruses #virology
Phylodynamics of deer tick virus in North America
Abstract. The burden of ticks and the pathogens they carry is increasing worldwide. Powassan virus (POWV, Flaviviridae: Flavivirus), the only known North AmericMcMinn, Rebekah J (Oxford University Press)
Eric Pyrrhus
in reply to Frank Aylward • • •"We use a multifaceted approach to evaluate the emergence of... deer tick virus (DTV), in parts of North America where human cases occur."
"Detection of... neutralizing antibodies in Northeastern hunter-killed deer increased from 4% in 1979 to 91% in 2010."
"DTV population expansion would be consistent with population genetic studies of I. scapularis ticks and another pathogen it transmits, Borrelia burgdorferi, the spirochete that causes Lyme disease."
Frank Aylward reshared this.
Eric Pyrrhus
in reply to Eric Pyrrhus • • •"Of Murines and Humans: Modeling Persistent Powassan Disease in C57BL/6 Mice"
https://doi.org/10.1128/mbio.03606-22
😲 Specifically, the authors found that the #virus may persist in the brain without creating infectious particles, just as non-infectious measles can persist in the brain indefinitely — and be fatal:
https://pubmed.ncbi.nlm.nih.gov/6879001/
#virology #ViralPersistence
Persistent measles infection of the central nervous system: subacute sclerosing panencephalitis - PubMed
PubMedElzi Volk
in reply to Eric Pyrrhus • • •Frank Aylward
in reply to Elzi Volk • • •