2) #Metagenomics is now maturing to a point where large-scale worldwide meta-analyses become possible, with enough public data to study rare species in broad contexts. This is possible only if the raw data and, above all, the associated #metadata are public and accessible.
So please, do not keep the metadata behind closed doors, and adopt an #openscience policy whenever possible đ
Dismissing the apparent contradiction of having toxigenic #Cdiff in healthy infants by saying âinfants have immature intestinal mucosa that lacks the receptors for Cdiff toxinsâ (a claim dating back to '86 and never confirmed in full-term human infants) is not enough anymore.
While we are aware of the intrinsic limitations of our metag. approach, we hope this study will invite further interdisciplinary investigation on the dynamics at play between #Cdifficile, its #toxins and the #infant mucosa
Frank Aylward
Unknown parent • • •Pamela Ferretti
Unknown parent • • •2) #Metagenomics is now maturing to a point where large-scale worldwide meta-analyses become possible, with enough public data to study rare species in broad contexts. This is possible only if the raw data and, above all, the associated #metadata are public and accessible.
So please, do not keep the metadata behind closed doors, and adopt an #openscience policy whenever possible đ
Pamela Ferretti
Unknown parent • • •Dismissing the apparent contradiction of having toxigenic #Cdiff in healthy infants by saying âinfants have immature intestinal mucosa that lacks the receptors for Cdiff toxinsâ (a claim dating back to '86 and never confirmed in full-term human infants) is not enough anymore.
While we are aware of the intrinsic limitations of our metag. approach, we hope this study will invite further interdisciplinary investigation on the dynamics at play between #Cdifficile, its #toxins and the #infant mucosa