Excessive olfactory memory in the insomniac fruit fly mutant:
"we report our surprising findings that insomniac (inc) Drosophila short sleep mutants, which lack a crucial adaptor protein for the autism-associated Cullin-3 ubiquitin ligase, exhibited excessive olfactory memory."
And then the paper goes on to inquire into the molecular basis of this, and reports:
"find that a mild attenuation of Protein Kinase A (PKA) signaling specifically rescued the sleep and longevity phenotypes of inc mutants. Surprisingly, this mild PKA signaling reduction further boosted the excessive memory in inc mutants, coupled with further exaggerated mushroom body overgrowth phenotypes."
From:
"Cognitive hyperplasticity drives insomnia", by Huang et al. (Sigrist lab) 2024
https://www.biorxiv.org/content/10.1101/2024.07.16.603670v1.full
Albert Cardona
in reply to Albert Cardona • • •By the way the tools available nowadays for discovering scientific literature are remarkable. Two examples:
#SemanticScholar lists actually related and interesting papers:
https://www.semanticscholar.org/paper/Cognitive-hyperplasticity-drives-insomnia-Huang-Piao/9b5da8eeed335a34a6f8e5729033b22f07c7cf41#related-papers
And so does #Sciety @sciety but offering a different set of related papers:
https://sciety.org/articles/activity/10.1101/2024.07.16.603670
#ScientificPublishing
Cognitive hyperplasticity drives insomnia
Sciety