Neurons and particularly their synapses are so dependent on ATP produced by mitochondria that the mislocalization of the latter has strong implications for neural diseases:

"Identifying and targeting abnormal mitochondrial localization associated with psychoses", Haghighi et al. 2025 (Anne Carpenter's lab).
biorxiv.org/content/10.1101/20…

Interestingly, mitochondrial mislocalization within the cell occurs not just in neurons but in all cells, hence this study focused on skin cells (!). Much easier to sample and study.

#neuroscience #mitochondria #NeuralDisease

One fully-funded PhD position on mosquito behaviour available at the Insect Neuro Lab in Durham University, with Olena Riabinina @lena_r , plus a second one that depends on securing a fellowship.
insectneurolab.com/vacancies/

#neuroscience #insects #PhDPosition #PhDJobs

Excessive olfactory memory in the insomniac fruit fly mutant:

"we report our surprising findings that insomniac (inc) Drosophila short sleep mutants, which lack a crucial adaptor protein for the autism-associated Cullin-3 ubiquitin ligase, exhibited excessive olfactory memory."

And then the paper goes on to inquire into the molecular basis of this, and reports:

"find that a mild attenuation of Protein Kinase A (PKA) signaling specifically rescued the sleep and longevity phenotypes of inc mutants. Surprisingly, this mild PKA signaling reduction further boosted the excessive memory in inc mutants, coupled with further exaggerated mushroom body overgrowth phenotypes."

From:
"Cognitive hyperplasticity drives insomnia", by Huang et al. (Sigrist lab) 2024
biorxiv.org/content/10.1101/20…

#Drosophila #neuroscience #LearningAndMemory

Interesting that this study on infant brain development is not done with fMRI but with fNIRS (functional near-infrared spectroscopy [1]). And concerning to read about the complete reliance on software provided opaquely by a company for the analysis: "As all fNIRS data preprocessing was carried out on MATLAB-based toolboxes, no custom scripts are available."

[1] fNIRS measures more or less the same as fMRI: blood flow. "Using fNIRS, brain activity is measured by using near-infrared light to estimate cortical hemodynamic activity which occur in response to neural activity." en.wikipedia.org/wiki/Function…

#neuroscience

optical technique for monitoring brain activity

^{Contributors to Wikimedia projects (Wikimedia Foundation, Inc.)}

Today @eLife has reached 1,000 manuscript submissions using the new model, Reviewed Preprints elifesciences.org/about/peer-r…

See all published Reviewed Preprints elifesciences.org/reviewed-pre…

Within themes, #eLife makes no distinction between old-style articles (where editors decided whether a manuscript is accepted) and reviewed preprints (where authors decide instead). Keep in mind both have the reviews attached, including as of recently a brief assessment paragraph summarizing, with a controlled vocabulary, the significance of findings and, more importantly, the strength of evidence.

See the subset of #eLife publications tagged as #neuroscience elifesciences.org/subjects/neu…

#ScientificPublishing #academia #eLife

Reviewed Preprints

Preprints that have been invited for review by eLife are published as Reviewed Preprints and include an eLife assessment, public reviews and a response from the authors (if available).

^eLife

"An analysis of about 450,000 electronic health records has found a link between infections from influenza and other common viruses and an elevated risk of having a neurodegenerative condition such as Alzheimer’s or Parkinson’s disease later in life."

#Virology #AlzheimersDisease #NeuroDegeneration #Neuroscience #Immunology

nature.com/articles/d41586-023…

Massive health-record review links viral illnesses to brain disease

Study ties common viruses such as flu to Alzheimer’s and other conditions — but the analysis has limitations, researchers warn.

^{Kozlov, Max}

Open Science #OpenScience #OpenData #neuroscience #astrocytes #zebrafish

We published whole-brain neuron+glia light-sheet calcium imaging data...

... from Mu et al., Cell 2019, 12 fish, 5.9 TB, >1,000,000 cells total + behavior, NWB format

Data: dandiarchive.org/dandiset/0003…

Paper: cell.com/cell/fulltext/S0092-8…

Thank you CatalystNeuro + authors for implementing, and
Simons Foundation Global Brain for supporting this effort!

Data is open for everyone to use. We are also happy to actively collaborate!

A post-migration re-#introduction!

I’m currently a postdoc in Marlene Behrmann’s lab at Carnegie Mellon. I’m broadly interested in understanding the #psychology and #neuroscience underlying the #development of cognitive abilities such as categorization.

Recently I’ve been exploring the broader biological network that may support may object categorization (e.g., doi.org/10.1016/j.tics.2022.09…) and the #computational processes that may support few-shot categorization in infancy (e.g., doi.org/10.7554/eLife.74943)

Perception of an object’s global shape is best described by a model of skeletal structure in human infants

Six- to twelve-month old infants, who have little linguistic or object experience, classify objects by relying on a invariant representation of global shape known as the shape skeleton.

^{Vladislav Ayzenberg (eLife Sciences Publications, Ltd)}

I just made an new Mastodon instance focused on #neuroscience at synapse.cafe . I'd like this to be a cozy space to discuss the wonders of the brain, from cells to thoughts. If you do research in neuroscience or even have a general interest in it, come by and check it out!

#instance #mastodon

Synapse Cafe

A Mastodon instance for anyone interested in neuroscience, from cell biology to electrophysiology to behavior to clinical applications, anyone is welcome!

^{Mastodon hosted on synapse.cafe}

#Introduction to "1-paper-a-day 2022"
After countless conversations that I read too little, I decided to read 1 paper on every workday of 2022 and point to them on SocMedia.

Papers are in the general area of #cognitive + #sensorimotor #neuroscience, including meta-stuff such as #OpenScience.

List of papers so far with links to tweets - toots from now on…
public.3.basecamp.com/p/pHVdbn…

I'm at #133 – doesn’t mean I had lots of vacation but rather that sticking to the plan hasn't been easy ;)

#introduction

Hi all,
I am a Group Leader at HHMI Janelia Research Campus, working on the systems #neuroscience of flexible behavior and #learning, #brain-body communication, #microscopy, #computation, #astrocytes, and large #networks.

We enjoy collaborating, including with computational neuroscientists who want to take a look at whole-brain neuron + behavior data! Get in touch 😀

Websites: ahrenslab.org/
janelia.org/lab/ahrens-lab
Google Scholar: scholar.google.com/citations?u…

Ahrens Lab @Janelia Research Campus

Website of the Ahrens Lab at HHMI Janelia Research Campus

^{www.ahrenslab.org}