Neurons and particularly their synapses are so dependent on ATP produced by mitochondria that the mislocalization of the latter has strong implications for neural diseases:
"Identifying and targeting abnormal mitochondrial localization associated with psychoses", Haghighi et al. 2025 (Anne Carpenter's lab).
biorxiv.org/content/10.1101/20…
Interestingly, mitochondrial mislocalization within the cell occurs not just in neurons but in all cells, hence this study focused on skin cells (!). Much easier to sample and study.
Frank Aylward
in reply to Albert Cardona • • •