Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk

nature.com/articles/s41588-023…

#Transposons #genomics

Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk - Nature Genetics

MEGAnE is a new tool to detect and genotype mobile element variants (MEVs) from short-read whole-genome sequencing datasets. Genetic analyses implicate MEVs as population-specific drivers of gene expression variation and disease risk.

^Nature

Unexplored diversity and ecological functions of transposable phages

nature.com/articles/s41396-023…

#phages #viruses #transposons

Unexplored diversity and ecological functions of transposable phages - The ISME Journal

The ISME Journal - Unexplored diversity and ecological functions of transposable phages

^Nature

Re-reading a excellent paper by @ariskatzourakis on Maverick/Polinton mobile elements:

Phylogenomics of the Maverick Virus-Like Mobile Genetic Elements of Vertebrates

Nicely underscores the emerging importance of large DNA transposons/EVEs in eukaryotic evolution

"We conclude that vertebrate Mavericks form an ancient lineage of aquatic dsDNA viruses which are probably still functional in some vertebrate lineages."

academic.oup.com/mbe/article/3…

#transposons #genetics #evolution

Phylogenomics of the Maverick Virus-Like Mobile Genetic Elements of Vertebrates

Abstract. Mavericks are virus-like mobile genetic elements found in the genomes of eukaryotes. Although Mavericks encode capsid morphogenesis homologs, their vi

^{Barreat, Jose Gabriel Nino (Oxford University Press)}

Nice review on the increasing importance of large #transposons :

Giant Transposons in Eukaryotes: Is Bigger Better?

academic.oup.com/gbe/article/1…

"...the size limitations previously placed on mobilizable DNA units in eukaryotes may have been due in part to our inability to assemble large contiguous stretches of repetitive DNA in complex genomes."

#genetics #genomics

Giant Transposons in Eukaryotes: Is Bigger Better?

Abstract. Transposable elements (TEs) are ubiquitous in both prokaryotes and eukaryotes, and the dynamic character of their interaction with host genomes brings

^{Arkhipova, Irina R (Oxford University Press)}

Reading up on the role of transposons in genome evolution, and finding this classic review from a few years ago very helpful:

Ten things you should know about transposable elements

genomebiology.biomedcentral.co…

#genomics #transposons #evolution #genetics

Ten things you should know about transposable elements - Genome Biology

Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation.

^{BioMed Central}