Excited to announce our article, "EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals" was just published in Nature Communications!

We demonstrate that it's possible to infer how genes work together using only sequencing data by leveraging correlated signals of evolution. Check it out at the link below!

#genomics #bioinformatics #rstats #genetics #evolution #biology

nature.com/articles/s41467-025…

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals - Nature Communications

Despite having structures for most proteins, we still do not know their function. Here, authors introduce EvoWeaver, a de novo method to identify genes working together using evolutionary information.

^Nature

I'm extracting DNA from the legs of spiders which were euthanized by freezing in a household freezer. In almost every spider, the DNA shows a banding pattern associated with apoptosis. Why would there be so much programed cell death in the legs of spiders? Had it already happened naturally? Was it induced during the freezing process? I do not see this happening in other organisms using the same extraction procedure.

Each lane is DNA extracted from a different spider.

#genetics #DNA #apoptosis

PhD studentship to characterise aphid immune evolution. Lots to uncover in an insect group with major ecological & economic impact. Aphid systemic immunity is a black box. The interested PhD candidate will both provide one of the first detailed descriptions of aphid immunity, but also uncover principles of immune evolution.

Deadline July 29th at #UoExeter
Email or DM for details🐘 📩
m.hanson@exeter.ac.uk

#Genomics #Aphid #Genetics #Immunity #Evolution #Drosophila

Gotta check these out!

Robust, scalable, and informative clustering for diverse biological networks

genomebiology.biomedcentral.co…

#bioinformatics #genomics #genetics #statistics

Robust, scalable, and informative clustering for diverse biological networks - Genome Biology

Clustering molecular data into informative groups is a primary step in extracting robust conclusions from big data.

^{BioMed Central}

Come work with us! I have a PhD position available to help understand which mutations in the non-coding parts of coding transcripts have functional consequences in Stem Cells.

We will using genome wide mesaurement of the effect of variation in miRNA binding sites to address when vairation causes changes in regulation and when it doesn't.

Mixed wetlab, bioinformatics and statistics project.

findaphd.com/phds/project/whit…

#phdPosition #PhD #bioinformatics #UTR #miRNA #genetics

White Rose BBSRC DTP: How can we identify variants in untranslated RNA that affect stem-cells at University of Sheffield on FindAPhD.com

PhD Project - White Rose BBSRC DTP: How can we identify variants in untranslated RNA that affect stem-cells at University of Sheffield, listed on FindAPhD.com

^{www.FindAPhD.com}

Seeking applicants for #PhD projects on #genetics & #language:

1) Deciphering roles of rare genetic variants in developmental speech/language disorders. This project studies impacts of pathogenic gene disruptions by integrating data from clinical & speech/language profiles of affected patients with lab-based analyses in human neuronal models (e.g. brain organoids).

2) Mapping language-relevant genetic effects on brain variability using normative modelling. Here, we apply normative modelling to large-scale imaging & DNA data from the general population, to uncover heterogeneous effects of language-relevant genetic variants.

3) Genetic architecture of the human language network. In this project, we employ advanced neuroimaging techniques to map neural circuits involved in language processing, characterize interindividual differences in their properties, & associate them with DNA variation in unique cohorts.

Applications due before Jan 8th 2024. More info here: mpi.nl/imprs-phd-fellowships-2…

Hey Mastodon! 👋 Here is our #introduction post: We are the Data Visualization Lab at Khoury College of Computer Sciences at Northeastern University. You can find more about our work here: vis.khoury.northeastern.edu/

We'd love to be connected to more folks and labs in the realms of #DataVisualization #HCI #xAI #AR #VR #VisualAnalytics #PhD #Research

Our lab has been applying visualization to domain areas like #accessibility #UAVs #Genetics #Privacy #Pedagogy #Networks #GraphTheory

Say hi!

Cool paper! Also glad we are moving towards Patescibacteria and not CPR:

"Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle"

doi.org/10.1016/j.cell.2023.08…

#microbiology #genomics #genetics

Re-reading a excellent paper by @ariskatzourakis on Maverick/Polinton mobile elements:

Phylogenomics of the Maverick Virus-Like Mobile Genetic Elements of Vertebrates

Nicely underscores the emerging importance of large DNA transposons/EVEs in eukaryotic evolution

"We conclude that vertebrate Mavericks form an ancient lineage of aquatic dsDNA viruses which are probably still functional in some vertebrate lineages."

academic.oup.com/mbe/article/3…

#transposons #genetics #evolution

Phylogenomics of the Maverick Virus-Like Mobile Genetic Elements of Vertebrates

Abstract. Mavericks are virus-like mobile genetic elements found in the genomes of eukaryotes. Although Mavericks encode capsid morphogenesis homologs, their vi

^{Barreat, Jose Gabriel Nino (Oxford University Press)}

Nice review on the increasing importance of large #transposons :

Giant Transposons in Eukaryotes: Is Bigger Better?

academic.oup.com/gbe/article/1…

"...the size limitations previously placed on mobilizable DNA units in eukaryotes may have been due in part to our inability to assemble large contiguous stretches of repetitive DNA in complex genomes."

#genetics #genomics

Giant Transposons in Eukaryotes: Is Bigger Better?

Abstract. Transposable elements (TEs) are ubiquitous in both prokaryotes and eukaryotes, and the dynamic character of their interaction with host genomes brings

^{Arkhipova, Irina R (Oxford University Press)}

Current advances in primate genomics: novel approaches for understanding evolution and disease

nature.com/articles/s41576-022…

#genomics #genetics #evolution

Current advances in primate genomics: novel approaches for understanding evolution and disease - Nature Reviews Genetics

In this Review, the authors describe how advances in comparative primate genomics — complemented by multi-layered omic resources and primate cell systems — are providing insights into the evolution of primates and the genetic underpinnings of key tra…

^Nature

🧬Jennifer Doudna and Emmanuelle Charpentier.
Nobel Prize in Chemistry for developing precise DNA-editing technology, CRISPR.

#genetics #science #scientists #womeninscience #illustration #mastoart #art #portrait #ciencia #divulgacion #digitalart

I’m doing a project featuring little-known women of science as a part of my studies as a lab technician.
I’ll be drawing some portraits and illustrating the research and discoveries of some interesting scientists✨

Let’s start!

🧬Nettie Stevens. American geneticist who discovered chromosomes X/Y by studying Mealworms (Tenebrio molitor)

#science #womeninstem #womeninscience #molecularbiology #genetics #mastoart #portrait #research #art #ciencia

Reading up on the role of transposons in genome evolution, and finding this classic review from a few years ago very helpful:

Ten things you should know about transposable elements

genomebiology.biomedcentral.co…

#genomics #transposons #evolution #genetics

Ten things you should know about transposable elements - Genome Biology

Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation.

^{BioMed Central}