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The human #OAS1 protein restricts #SARSCoV2 replication, but #HorseshoeBat OAS1 has lost this ability. @spyroslytras @WilsonLabCVR &co resurrect the 60,000,000 yr old ancestral bat OAS1, revealing how this ancient #antiviral mechanism was lost #PLOSBiology https://plos.io/3N6fWPx

Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication

The human OAS1 protein restricts SARS-CoV-2 replication, but the horseshoe bat OAS1 has lost this ability.
plos.io
#plosbiology #sarscov2 #Antiviral #horseshoebat #oas1

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