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Items tagged with: Antiviral


The human #OAS1 protein restricts #SARSCoV2 replication, but #HorseshoeBat OAS1 has lost this ability. @spyroslytras @WilsonLabCVR &co resurrect the 60,000,000 yr old ancestral bat OAS1, revealing how this ancient #antiviral mechanism was lost #PLOSBiology https://plos.io/3N6fWPx


Content warning: Long thread/24


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"As of 2 December 2022, over 82,000 human #mpox (or #monkeypox) cases have been laboratory confirmed in 110 countries worldwide."

And sporadic reports are still coming in:
https://c.im/@andrew_a_lover/109673550181706348

This may be what a very very very slow pandemic looks like.
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As a step towards the development of an #antiviral, (Peng et al., 2022) recently elucidated the structure of the mpox DNA polymerase:

"Structure of monkeypox #virus DNA polymerase holoenzyme"
https://doi.org/10.1126/science.ade6360
#virology @virology

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