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Items tagged with: mpox
The ongoing and rapidly expanding outbreak of #mpox in DRC is concerning for many reasons incl.:
- Itβs clade I MPXV (different from clade II causing global outbreak)
- First time sexual transmission has been documented for clade I MPXV
- First time spreading in Kinshasa
https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON493
Item
Mpox is an infectious disease caused by monkeypox virus (MPXV), which is endemic in densely forested regions of West, Central and East Africa, particularly in the northern and central regions of the Democratic Republic of the Congo.www.who.int
Study launched to find out more about mpox immunity
A new study aims to better understand how the body reacts to the mpox virus and produces antibodies.UK Health Security Agency (GOV.UK)
π¦ A Few More #Mpox ( #MonkeyPox) Pandemic Updates π¦
"Assuming APOBEC-editing is characteristic of [mpox] infection in human hosts, we propose an APOBEC clock that β at a rate of ~6 APOBEC3 mutations per year β estimates [mpox] has been circulating in humans since 2016."
https://www.biorxiv.org/content/10.1101/2023.01.23.525187v1
#virus #virology @virology #epidemiology #InfectiousDisease
Putative APOBEC3 deaminase editing in MPXV as evidence for sustained human transmission since at least 2016
Mpox is often described as being endemic in West and Central Africa as a zoonotic disease that transmits through contact with the reservoir rodent host, likely a species of African squirrel.bioRxiv
Interesting report on #Mpox #virus:
(AKA #MonkeyPox or #MPXV)
"We monitored SARS-CoV-2 & MPXV genomes in the air... in Madrid nightclubs... in 2022.
...
MPXV in the air had increased considerably on Aug 8, with 57% of positive samples containing more than 100 genomes per [cubic meter]; this date coincided with the peak incidence of mpox in Spain."
The authors suggest that air sampling might be a useful surveillance method.
#virology #epidemiology #InfectiousDisease
https://doi.org/10.1016/S2666-5247(23)00104-0
"As of 2 December 2022, over 82,000 human #mpox (or #monkeypox) cases have been laboratory confirmed in 110 countries worldwide."
And sporadic reports are still coming in:
https://c.im/@andrew_a_lover/109673550181706348
This may be what a very very very slow pandemic looks like.
π¦
As a step towards the development of an #antiviral, (Peng et al., 2022) recently elucidated the structure of the mpox DNA polymerase:
"Structure of monkeypox #virus DNA polymerase holoenzyme"
https://doi.org/10.1126/science.ade6360
#virology @virology
Andrew Lover (@andrew_a_lover@c.im)
Attached: 1 image New #mpox in CDC EID (title only); seems... important. π Anecdata ----> Case reports ----> (πππ©'π¨ ππͺπ¨π© π¨π©π€π₯ π§ππππ© πππ§π, π¨πππ‘π‘ π¬π? ππ€ π£πππ π©π€ ππ€π£π©ππ£πͺπ.) Case series ----> Epi studies ----> New Knowledge. https://wwwnc.cdc.C.IM