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Items tagged with: sarscov2
Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication
The human OAS1 protein restricts SARS-CoV-2 replication, but the horseshoe bat OAS1 has lost this ability.plos.io
The Economist used global excess deaths to arrive at the true death toll from the pandemic with a 95% confidence interval.
"Although the official number of deaths caused by #COVID19 is now 7m, our single best estimate is that the actual toll is 27.5m people. We find that there is a 95% chance that the true value lies between 17.8m and 30.8m additional deaths."
#Covid #SarsCov2 #GlobalExcessDeaths
https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates
A third of US deer have had COVID—and they infected humans at least 3 times
New study builds on data suggesting white-tailed deer could be a virus reservoir.Ars Technica
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1195871/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit
SARS-CoV-2 and the host-immune response
The SARS-CoV-2 pandemic and the COVID-19 disease have affected everyone globally, leading to one of recorded history’s most significant research surges. As our knowledge evolves, our approaches to the virus and treatments must also evolve.Frontiers
▫️ Any protein expressed is an ‘antigenic liability’ for the virus
▫️ MHC class I and II ‘see’ different antigen repertoires
▫️ Spike is just one of many important viral proteins
1/3
https://www.biorxiv.org/content/10.1101/2023.05.26.542482v1
The HLA-II immunopeptidome of SARS-CoV-2
Targeted synthetic vaccines have the potential to transform our response to viral outbreaks; yet the design of these vaccines requires a comprehensive knowledge of viral immunogens, including T-cell epitopes.bioRxiv
Hmm...
A recent paper looked at evolution of #SARSCoV2 *within* different tissues, which might raise a few questions.
Specifically, the authors found evidence that the #virus might evolve independently in different tissues, especially in immune-privileged sites.
But that's not all...
"High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection"
https://www.nature.com/articles/s41467-022-34256-y
#virology #epidemiology #InfectiousDisease
High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection - Nature Communications
Here, by high-resolution SARS-CoV-2 sequencing, genomic and transcriptomic analyses from tissue samples, Normandin et al.Nature
https://www.covidsafedentists.ca/
#sarscov2 #covid #dentist