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Items tagged with: SARSCoV2
I am fascinated by how viruses evolve - and not just since #SARSCoV2 has shown us at the global stage how consequential virus evolution can be for us.
In my new story in Science I got to explore how researchers are probing deeper into the past with old RNA virus genome.
So a thread…
Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication
The human OAS1 protein restricts SARS-CoV-2 replication, but the horseshoe bat OAS1 has lost this ability.plos.io
The Economist used global excess deaths to arrive at the true death toll from the pandemic with a 95% confidence interval.
"Although the official number of deaths caused by #COVID19 is now 7m, our single best estimate is that the actual toll is 27.5m people. We find that there is a 95% chance that the true value lies between 17.8m and 30.8m additional deaths."
A third of US deer have had COVID—and they infected humans at least 3 times
New study builds on data suggesting white-tailed deer could be a virus reservoir.Ars Technica
▫️ Any protein expressed is an ‘antigenic liability’ for the virus
▫️ MHC class I and II ‘see’ different antigen repertoires
▫️ Spike is just one of many important viral proteins
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biorxiv.org/content/10.1101/20…
The HLA-II immunopeptidome of SARS-CoV-2
Targeted synthetic vaccines have the potential to transform our response to viral outbreaks; yet the design of these vaccines requires a comprehensive knowledge of viral immunogens, including T-cell epitopes.bioRxiv
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Hmm...
A recent paper looked at evolution of #SARSCoV2 *within* different tissues, which might raise a few questions.
Specifically, the authors found evidence that the #virus might evolve independently in different tissues, especially in immune-privileged sites.
But that's not all...
"High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection"
nature.com/articles/s41467-022…
#virology #epidemiology #InfectiousDisease
High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection - Nature Communications
Here, by high-resolution SARS-CoV-2 sequencing, genomic and transcriptomic analyses from tissue samples, Normandin et al.Nature
Covid-safe dentist registry for Canada, the US, Brazil, Australia, Indonesia, NZ, and the UK (courtesy of @neroden)