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How RNA viruses can use their dsRNA intermediate state as a de facto latent state, facilitating viral persistence.
Positive single-stranded #RNA viruses have a replication cycle that includes a double-stranded RNA (dsRNA) intermediate state.
#virology @virology #virus #virome #ViralPersistence #InfectiousDisease
Hmm...
A recent paper looked at evolution of #SARSCoV2 *within* different tissues, which might raise a few questions.
Specifically, the authors found evidence that the #virus might evolve independently in different tissues, especially in immune-privileged sites.
But that's not all...
"High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection"
https://www.nature.com/articles/s41467-022-34256-y
#virology #epidemiology #InfectiousDisease
High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection - Nature Communications
Here, by high-resolution SARS-CoV-2 sequencing, genomic and transcriptomic analyses from tissue samples, Normandin et al.Nature
🦠 A Few More #Mpox ( #MonkeyPox) Pandemic Updates 🦠
"Assuming APOBEC-editing is characteristic of [mpox] infection in human hosts, we propose an APOBEC clock that – at a rate of ~6 APOBEC3 mutations per year – estimates [mpox] has been circulating in humans since 2016."
https://www.biorxiv.org/content/10.1101/2023.01.23.525187v1
#virus #virology @virology #epidemiology #InfectiousDisease
Putative APOBEC3 deaminase editing in MPXV as evidence for sustained human transmission since at least 2016
Mpox is often described as being endemic in West and Central Africa as a zoonotic disease that transmits through contact with the reservoir rodent host, likely a species of African squirrel.bioRxiv
Interesting report on #Mpox #virus:
(AKA #MonkeyPox or #MPXV)
"We monitored SARS-CoV-2 & MPXV genomes in the air... in Madrid nightclubs... in 2022.
...
MPXV in the air had increased considerably on Aug 8, with 57% of positive samples containing more than 100 genomes per [cubic meter]; this date coincided with the peak incidence of mpox in Spain."
The authors suggest that air sampling might be a useful surveillance method.
#virology #epidemiology #InfectiousDisease
https://doi.org/10.1016/S2666-5247(23)00104-0
One recurring problem with #epidemiology of #flavivirus #InfectiousDisease is that antibody tests for one flavivirus happen to be highly crossreactive with other flaviviruses.
That is a problem addressed in:
"Co-Circulation of West Nile, Usutu, and Tick-Borne Encephalitis Viruses in the Same Area: A Great Challenge for Diagnostic and Blood and Organ Safety"
https://www.mdpi.com/1999-4915/15/2/366
@virology
Co-Circulation of West Nile, Usutu, and Tick-Borne Encephalitis Viruses in the Same Area: A Great Challenge for Diagnostic and Blood and Organ Safety
Viral infections caused by viruses from the family Flaviviridae such as Zika (ZIKV), Dengue (DENV), yellow fever (YFV), tick-borne encephalitis (TBEV), West Nile (WNV), and Usutu (USUV) are some of the most challenging diseases for recognition in cli…MDPI
https://apply.interfolio.com/118539
RT 😀
😲 Two recent studies from China look at the truly wide diversity of RNA viruses found in ticks.
"Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China"
https://doi.org/10.1371/journal.pntd.0011017
"Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes"
https://www.nature.com/articles/s41564-022-01275-w
A lot of insights in these two studies, so I'll just point out a few things that I personally found interesting.
#virology @virology #RNA #virus #virome #InfectiousDisease
Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China
Author summary Ticks are important vectors to transmit many infectious agents. In recent years, many novel tick-borne viruses associated with human illness, including Alongshan virus, Songling virus, and Beiji nairovirus, have been identified in nort…doi.org