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Items tagged with: RNA
https://www.nature.com/articles/d41586-023-03364-0?utm_medium=Social#ref-CR3
Viral infection triggers the production of cyclic GMP–AMP synthase (cGAS), an enzyme that synthesizes cyclic GMP–AMP (cGAMP) to activate the downstream effector response.
https://www.science.org/doi/epdf/10.1126/science.1232458
A viral RNA molecule activates the bacterial immune system during infection
A bacterial defence system against bacteriophage infection recognizes a specific structured viral RNA to start producing cyclic nucleotides for immune signalling.www.nature.com
#CRISPR #DNA #RNA #Microbiology #sflorg
https://www.sflorg.com/2023/10/mcb10142302.html
Thousands of programmable DNA-cutters found in algae, snails, and other organisms
New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.www.sflorg.com
New BMJ Feature:
"Where do viruses hide in the human body?"
https://doi.org/10.1136/bmj.p1156
#RNA #virus #virology @virology #ViralPersistence
Where do viruses hide in the human body?
The question of how SARS-CoV-2 persists in the body has refocused scientists on the question of where viruses persist in humans more generally.The BMJ
#ScienceMastodon #RNA #mRNA #preprint #mpinat
Nuclear export is a limiting factor in eukaryotic mRNA metabolism
The eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and degradation. To quantify all these processes simultaneously, we perform thiol-linked alkylation after metabolic labeling of RNA with 4-thiouridine (4sU), followed by seque…bioRxiv
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How RNA viruses can use their dsRNA intermediate state as a de facto latent state, facilitating viral persistence.
Positive single-stranded #RNA viruses have a replication cycle that includes a double-stranded RNA (dsRNA) intermediate state.
#virology @virology #virus #virome #ViralPersistence #InfectiousDisease
Holy Crap.
If confirmed, we'll have to figure out how to categorize 180,000 newly discovered viruses.
@RNA has called this the "Platinum Age of Virus Discovery"!
"Identification of #RNA viruses is currently limited to those with sequence similarity to a known #virus, such that... the 'dark matter' of the virosphere remains challenging to detect.
We developed a deep learning algorithm [which] integrates both sequence and structural information..."
https://www.biorxiv.org/content/10.1101/2023.04.18.537342v1
#virology @virology
Artificial intelligence redefines RNA virus discovery
RNA viruses are diverse components of global ecosystems. The metagenomic identification of RNA viruses is currently limited to those with sequence similarity to known viruses, such that highly divergent viruses that comprise the “dark matter” of the …bioRxiv
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The authors also found hints of viral "latency" associated with longer infection times.
This would suggest that the rate of viral replication might slow down as the infection proceeds, possibly resulting in a quasi-latent state characterized by very low replication and protein synthesis.
How could this be? How could an #RNA virus slow its rate of viral replication and protein synthesis to help it to persist?
Well, here's just one possible way:
https://mstdn.science/@pyrrhus/109507942028202866
#ViralPersistence
😲 Two recent studies from China look at the truly wide diversity of RNA viruses found in ticks.
"Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China"
https://doi.org/10.1371/journal.pntd.0011017
"Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes"
https://www.nature.com/articles/s41564-022-01275-w
A lot of insights in these two studies, so I'll just point out a few things that I personally found interesting.
#virology @virology #RNA #virus #virome #InfectiousDisease
Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China
Author summary Ticks are important vectors to transmit many infectious agents. In recent years, many novel tick-borne viruses associated with human illness, including Alongshan virus, Songling virus, and Beiji nairovirus, have been identified in nort…doi.org