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Items tagged with: RNA

#microbiology #crispr #amoebas #RNA #algae #sflorg #dna #snails #fanzors

#Virus #virology #RNA #viralpersistence @u/virology

We have a new preprint online! A great collab with the Tresch lab in Cologne. We found that mRNA 🧬 export out of the nucleus is surprisingly slow and and a rate limiting step for mRNA metabolism. Take a look: biorxiv.org/content/10.1101/20…
#ScienceMastodon #RNA #mRNA #preprint #mpinat

Nuclear export is a limiting factor in eukaryotic mRNA metabolism

The eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and degradation. To quantify all these processes simultaneously, we perform thiol-linked alkylation after metabolic labeling of RNA with 4-thiouridine (4sU), followed by seque…
bioRxiv
#ScienceMastodon #preprint #RNA #mrna #MPINAT

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1/13
How RNA viruses can use their dsRNA intermediate state as a de facto latent state, facilitating viral persistence.

Positive single-stranded #RNA viruses have a replication cycle that includes a double-stranded RNA (dsRNA) intermediate state.

#virology @virology #virus #virome #ViralPersistence #InfectiousDisease

#Virus #virology #RNA #virome #infectiousdisease #viralpersistence @u/virology

Holy Crap.

If confirmed, we'll have to figure out how to categorize 180,000 newly discovered viruses.

@RNA has called this the "Platinum Age of Virus Discovery"!

"Identification of #RNA viruses is currently limited to those with sequence similarity to a known #virus, such that... the 'dark matter' of the virosphere remains challenging to detect.

We developed a deep learning algorithm [which] integrates both sequence and structural information..."

biorxiv.org/content/10.1101/20…
#virology @virology

Artificial intelligence redefines RNA virus discovery

RNA viruses are diverse components of global ecosystems. The metagenomic identification of RNA viruses is currently limited to those with sequence similarity to known viruses, such that highly divergent viruses that comprise the “dark matter” of the …
bioRxiv
#Virus #virology #RNA @Artem Babaian @u/virology

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2/2
The authors also found hints of viral "latency" associated with longer infection times.

This would suggest that the rate of viral replication might slow down as the infection proceeds, possibly resulting in a quasi-latent state characterized by very low replication and protein synthesis.

How could this be? How could an #RNA virus slow its rate of viral replication and protein synthesis to help it to persist?

Well, here's just one possible way:
mstdn.science/@pyrrhus/1095079…
#ViralPersistence

#RNA #viralpersistence

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1/6
😲 Two recent studies from China look at the truly wide diversity of RNA viruses found in ticks.

"Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China"
doi.org/10.1371/journal.pntd.0…

"Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes"
nature.com/articles/s41564-022…

A lot of insights in these two studies, so I'll just point out a few things that I personally found interesting.

#virology @virology #RNA #virus #virome #InfectiousDisease

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

Author summary Ticks are important vectors to transmit many infectious agents. In recent years, many novel tick-borne viruses associated with human illness, including Alongshan virus, Songling virus, and Beiji nairovirus, have been identified in nort…
doi.org
#Virus #virology #RNA #virome #infectiousdisease @u/virology

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