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Items tagged with: mrna
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective #mRNA #vaccines against COVID-19.
Despite all the known issues with these (& other) prizes, this one makes me particularly happy: it is extremely well deserved and (another) clear example of what basic science can do for humanity.
We have a new preprint online! A great collab with the Tresch lab in Cologne. We found that mRNA 🧬 export out of the nucleus is surprisingly slow and and a rate limiting step for mRNA metabolism. Take a look: biorxiv.org/content/10.1101/20…
#ScienceMastodon #RNA #mRNA #preprint #mpinat
#ScienceMastodon #RNA #mRNA #preprint #mpinat
Nuclear export is a limiting factor in eukaryotic mRNA metabolism
The eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and degradation. To quantify all these processes simultaneously, we perform thiol-linked alkylation after metabolic labeling of RNA with 4-thiouridine (4sU), followed by seque…bioRxiv