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Items tagged with: crispr

Sorry I missed this symposium at the #Denver #AAASmtg. If there’s interest, I can send the transcript of a similar event during the 2019 #Tennessee #STEAM Festival; “From Plato to #CRISPR : Communicating #Science through Story-telling.” #STEAMfest #SciComm

https://www.codrescu.com/happeningsappearances-1/2019/10/16/from-plato-to-crispr-communicating-science-through-storytelling


From Plato to CRISPR: Communicating Science through Storytelling — Andrei Codrescu

Third Annual Tennessee STEAM Festival @Middle Tennessee University Through his talk, From Plato to CRISPR , Andrei brings light and heat to the space between science and art
Andrei Codrescu
#science #Steam #scicomm #crispr #tennessee #denver #aaasmtg #steamfest

#Bacteriophages encode anti-CRISPR proteins that inactivate bacterial #CRISPR-Cas systems, allowing successful invasion, replication & integration. This study shows that #antiCRISPR protein AcrIIA1 induces degradation of #Cas9 in human cells #PLOSBiology https://plos.io/3uUGAos

Cas9 degradation in human cells using phage anti-CRISPR proteins

Bacteriophages encode anti-CRISPR proteins that inactivate CRISPR-Cas bacterial immune systems, allowing successful invasion, replication, and prophage integration.
plos.io
#plosbiology #crispr #bacteriophages #cas9 #anticrispr

A diverse set of species, from #snails to #algae to #amoebas, make programmable DNA-cutting enzymes called #Fanzors — and a new study from scientists at MIT’s McGovern Institute for Brain Research has identified thousands of them.
#CRISPR #DNA #RNA #Microbiology #sflorg
https://www.sflorg.com/2023/10/mcb10142302.html

Thousands of programmable DNA-cutters found in algae, snails, and other organisms

New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.
www.sflorg.com
#microbiology #crispr #amoebas #RNA #algae #sflorg #dna #snails #fanzors

#Rotifers have been studied for >100 years re #microevolution, #EcologicalDynamics & #ecotoxicology. This study presents a #CRISPR-based method for KO mutation of 1 or 2 alleles, and KI mutations, in rotifers with high efficiency @MBLscience #PLOSBiology https://plos.io/3Kb8CAC

Highly efficient CRISPR-mediated gene editing in a rotifer

Rotifers have been studied in the laboratory and field for over 100 years in investigations of microevolution, ecological dynamics and ecotoxicology.
plos.io
#plosbiology #crispr #ecotoxicology #ecologicaldynamics #microevolution #rotifers

Our fantastic post-bac, Yennifer Delgado presenting her work at the #huskyresearch UW undergrad research symposium today in Mary Gates Hall. "CRISPR Functional Screen Identifies HIV Dependency Factors That Support HIV Release From Latency"
She's off to graduate school at UCLA this summer. #virology #HIV #CRISPR
#HIV #crispr #virology #huskyresearch

Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy
https://www.nature.com/articles/s41564-022-01318-2
#phage #bacteria #crispr

Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy - Nature Microbiology

Deployment of some CRISPR-Cas systems stunts host growth by degrading all transcripts, but Listeria seeligeri reverses dormancy using restriction-modification-based phage DNA targeting.
Nature
#bacteria #crispr #phage

#phage + #Eggerthella + #CRISPR + mice + #gut = 👇

https://www.nature.com/articles/s41396-023-01358-4

Congrats to all !

CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice - The ISME Journal

The ISME Journal - CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice
Nature
#crispr #phage #eggerthella #gut

Many in vitro #CRISPR knock-in approaches use small molecule drugs to improve the efficiency of homology-directed repair, but these drugs may or may not be safe in vivo. In this paper from #NatureBiotechnology, the authors find that an FDA-approved therapy, fludarabine, can be used for a similar purpose. Still a long ways to go before any genetic knock-ins are routinely done in vivo, but making progress toward doing so safely: https://www.nature.com/articles/s41587-022-01240-2 #science #medicine #GeneEditing #AAV

Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice - Nature Biotechnology

Fludarabine-induced DNA damage pathways enhance the in vivo efficiency of homologous recombination-based gene editing.
Nature
#science #medicine #AAV #geneediting #naturebiotechnology #crispr

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