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Items tagged with: crispr

Sorry I missed this symposium at the #Denver #AAASmtg. If there’s interest, I can send the transcript of a similar event during the 2019 #Tennessee #STEAM Festival; “From Plato to #CRISPR : Communicating #Science through Story-telling.” #STEAMfest #SciComm

codrescu.com/happeningsappeara…

From Plato to CRISPR: Communicating Science through Storytelling — Andrei Codrescu

Third Annual Tennessee STEAM Festival @Middle Tennessee University Through his talk, From Plato to CRISPR , Andrei brings light and heat to the space between science and art
Andrei Codrescu
#science #Steam #scicomm #crispr #tennessee #denver #aaasmtg #steamfest

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#Bacteriophages encode anti-CRISPR proteins that inactivate bacterial #CRISPR-Cas systems, allowing successful invasion, replication & integration. This study shows that #antiCRISPR protein AcrIIA1 induces degradation of #Cas9 in human cells #PLOSBiology plos.io/3uUGAos

Cas9 degradation in human cells using phage anti-CRISPR proteins

Bacteriophages encode anti-CRISPR proteins that inactivate CRISPR-Cas bacterial immune systems, allowing successful invasion, replication, and prophage integration.
plos.io
#plosbiology #crispr #bacteriophages #cas9 #anticrispr

#microbiology #crispr #amoebas #RNA #algae #sflorg #dna #snails #fanzors

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#Rotifers have been studied for >100 years re #microevolution, #EcologicalDynamics & #ecotoxicology. This study presents a #CRISPR-based method for KO mutation of 1 or 2 alleles, and KI mutations, in rotifers with high efficiency @MBLscience #PLOSBiology plos.io/3Kb8CAC

Highly efficient CRISPR-mediated gene editing in a rotifer

Rotifers have been studied in the laboratory and field for over 100 years in investigations of microevolution, ecological dynamics and ecotoxicology.
plos.io
#plosbiology #crispr #ecotoxicology #ecologicaldynamics #microevolution #rotifers

#bacteria #crispr #phage

#crispr #phage #eggerthella #gut

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Many in vitro #CRISPR knock-in approaches use small molecule drugs to improve the efficiency of homology-directed repair, but these drugs may or may not be safe in vivo. In this paper from #NatureBiotechnology, the authors find that an FDA-approved therapy, fludarabine, can be used for a similar purpose. Still a long ways to go before any genetic knock-ins are routinely done in vivo, but making progress toward doing so safely: nature.com/articles/s41587-022… #science #medicine #GeneEditing #AAV

Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice - Nature Biotechnology

Fludarabine-induced DNA damage pathways enhance the in vivo efficiency of homologous recombination-based gene editing.
Nature
#science #medicine #AAV #geneediting #naturebiotechnology #crispr

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