1/6
🦠 A Few More #Mpox ( #MonkeyPox) Pandemic Updates 🦠

"Assuming APOBEC-editing is characteristic of [mpox] infection in human hosts, we propose an APOBEC clock that – at a rate of ~6 APOBEC3 mutations per year – estimates [mpox] has been circulating in humans since 2016."
biorxiv.org/content/10.1101/20…

#virus #virology @virology #epidemiology #InfectiousDisease

Putative APOBEC3 deaminase editing in MPXV as evidence for sustained human transmission since at least 2016

Mpox is often described as being endemic in West and Central Africa as a zoonotic disease that transmits through contact with the reservoir rodent host, likely a species of African squirrel.

^bioRxiv

3/6
The use of the only broad-spectrum #antivirals designed for DNA virus infections (brincidofovir & cidofovir) may be under-utilized for Mpox infections:

"A 48-year-old man with poorly controlled HIV presented with severe [mpox] infection, having completed 2 weeks of tecovirimat...
Despite a second, prolonged course of tecovirimat, he did not improve...
Intravenous cidofovir was given at 5 mg/kg; the patient made a noticeable improvement after the first IV dose..."
thelancet.com/journals/laninf/…

Use of cidofovir in a patient with severe mpox and uncontrolled HIV infection

A 48-year-old man with poorly controlled HIV presented with severe human monkeypox virus (hMPXV) infection, having completed 2 weeks of tecovirimat at another hospital.

^{The Lancet Infectious Diseases}

4/6
More discussion of how the use of the only broad-spectrum #antivirals designed for DNA virus infections (brincidofovir & cidofovir) may be under-utilized for Mpox infections:

"Oral Brincidofovir Therapy for Monkeypox Outbreak: A Focused Review on the Therapeutic Potential, Clinical Studies, Patent Literature, and Prospects"
mdpi.com/2227-9059/11/2/278

Oral Brincidofovir Therapy for Monkeypox Outbreak: A Focused Review on the Therapeutic Potential, Clinical Studies, Patent Literature, and Prospects

The monkeypox disease (MPX) outbreak of 2022 has been reported in more than one hundred countries and is becoming a global concern. Unfortunately, only a few treatments, such as tecovirimat (TCV), are available against MPX.

^MDPI

5/6
A first attempt at describing the post-acute effects of Mpox infection:

"The later consequences of the disease remain unknown. We, therefore, aimed to evaluate the medium- and long-term morbidity following the acute episode of mpox."
eurosurveillance.org/content/1…

6/6
Besides the large impact of the Mpox pandemic on Latin America, reports continue to come in from East Asia:

Taiwan reports two locally acquired Mpox infections:
outbreaknewstoday.com/taiwan-r…

Mpox acquired by a health care worker in South Korea via needle-stick injury:
wwwnc.cdc.gov/eid/article/29/5…

Taiwan reports 2 local monkeypox cases in Hsinchu County and Kaohsiung City - Outbreak News Today

NewsDesk @bactiman63 The Taiwan CDC announced Wednesday the 6th and 7th confirmed monkeypox cases in a man in his 40s in the north and a man in his 20s in the south. They live in Hsinchu County and Kaohsiung City, respectively.

^{News Desk (Outbreak News Today)}

7/6
Interesting report on #Mpox #virus:
(AKA #MonkeyPox or #MPXV)

"We monitored SARS-CoV-2 & MPXV genomes in the air... in Madrid nightclubs... in 2022.
...
MPXV in the air had increased considerably on Aug 8, with 57% of positive samples containing more than 100 genomes per [cubic meter]; this date coincided with the peak incidence of mpox in Spain."

The authors suggest that air sampling might be a useful surveillance method.

#virology #epidemiology #InfectiousDisease
doi.org/10.1016/S2666-5247(23)…