Awesome work from Rotem Sorek lab in our department:
Rotem's lab & others found this past decade >150 bacterial defense mechanisms against phages.
This new work, led by Erez Yirmiya, explores phage *anti-defense* mechanisms, and it's really cool!
#bacteria #bacteriophage #phages

https://www.nature.com/articles/s41586-023-06869-w

🎉 New preprint from the (MDM) lab:

🔗 https://www.biorxiv.org/content/10.1101/2023.11.22.567924v1

❓ How accurately can we predict diverse #bacteriophage bacteria-interactions from their #genomes only ?

🦠 We created a matrix of >38k #phage-#bacteria interactions to find out (=> AUROC 86%) & used our predictions to recommend tailored phage cocktails.

Predicting which phages infect which specific strains would allow to better fight bacterial infections and understand #microbial ecology.

1/n

#microbiology #virus #phagotherapy

Predicting phage-bacteria interactions at the strain level from genomes

Predicting how phages can selectively infect specific bacterial strains holds promise for developing novel approaches to combat bacterial infections and better understanding microbial ecology.

^bioRxiv

Characterization of crAss-like phage isolates highlights Crassvirales genetic heterogeneity and worldwide distribution

https://www.nature.com/articles/s41467-023-40098-z

#phages #bacteriophage #viruses

Characterization of crAss-like phage isolates highlights Crassvirales genetic heterogeneity and worldwide distribution - Nature Communications

Here, the authors report the isolation and genetic characterization of 25 unique crAss-like phages (termed “crAssBcn”) infecting Bacteroides intestinalis, and show that CrAssBcn phages are commonly found in fecal samples from people around the globe,…

^Nature