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https://www.nature.com/articles/d41586-023-03364-0?utm_medium=Social#ref-CR3
Viral infection triggers the production of cyclic GMP–AMP synthase (cGAS), an enzyme that synthesizes cyclic GMP–AMP (cGAMP) to activate the downstream effector response.
https://www.science.org/doi/epdf/10.1126/science.1232458
A viral RNA molecule activates the bacterial immune system during infection
A bacterial defence system against bacteriophage infection recognizes a specific structured viral RNA to start producing cyclic nucleotides for immune signalling.www.nature.com
> Both SARS-CoV-2 and non-COVID-19 acute respiratory infections are associated with a wide range of symptoms more than 4 weeks after the acute infection<
In other words, long Covid is a thing, but is not completely unique to Covid.
"Long-term symptom profiles after COVID-19 vs other acute respiratory infections: an analysis of data from the COVIDENCE UK study"
#COVID19 #longCOVID #influenza #URTI #infectiousdiseases #IDMastodon
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00428-5/fulltext?dgcid=raven_jbs_aip_email#%20
Interesting: *Vaginal Microbiota Transplantation (VMT)*
We're probably going to start seeing a lot more of this as we appreciate how microbiomes of different organs impact health and disease.
Personally the key is to have clinical measures of success, as here, not just measuring % of different species changing.
#IDMastodon #MedMastodon #AMR #antibiotics #microbiology #microbiome #transplant
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1195871/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit
SARS-CoV-2 and the host-immune response
The SARS-CoV-2 pandemic and the COVID-19 disease have affected everyone globally, leading to one of recorded history’s most significant research surges. As our knowledge evolves, our approaches to the virus and treatments must also evolve.Frontiers
Brazil develops the first vaccine against schistosomiasis, the disease of swollen bellies
The researchers are waiting for the WHO to approve the treatment, which is the first in the world to protect against a worm that infects 200 million people a year
JUN 14, 2023
