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Items tagged with: Antiviral
Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication
The human OAS1 protein restricts SARS-CoV-2 replication, but the horseshoe bat OAS1 has lost this ability.plos.io
Fediverse applications are frequently designed to be #antiviral - that is, to prevent spectacular spreads of information across the system.
It's possible - likely, even - that future Fediverse servers *will* be operated by commercial operators seeking to maximize attention in order to maximize revenue.
24/
embopress.org/doi/10.15252/emb…
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"As of 2 December 2022, over 82,000 human #mpox (or #monkeypox) cases have been laboratory confirmed in 110 countries worldwide."
And sporadic reports are still coming in:
c.im/@andrew_a_lover/109673550…
This may be what a very very very slow pandemic looks like.
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As a step towards the development of an #antiviral, (Peng et al., 2022) recently elucidated the structure of the mpox DNA polymerase:
"Structure of monkeypox #virus DNA polymerase holoenzyme"
doi.org/10.1126/science.ade636…
#virology @virology
Andrew Lover (@andrew_a_lover@c.im)
Attached: 1 image New #mpox in CDC EID (title only); seems... important. 👀 Anecdata ----> Case reports ----> (𝙇𝙚𝙩'𝙨 𝙟𝙪𝙨𝙩 𝙨𝙩𝙤𝙥 𝙧𝙞𝙜𝙝𝙩 𝙝𝙚𝙧𝙚, 𝙨𝙝𝙖𝙡𝙡 𝙬𝙚? 𝙉𝙤 𝙣𝙚𝙚𝙙 𝙩𝙤 𝙘𝙤𝙣𝙩𝙞𝙣𝙪𝙚.) Case series ----> Epi studies ----> New Knowledge. https://wwwnc.cdc.C.IM