Neurons and particularly their synapses are so dependent on ATP produced by mitochondria that the mislocalization of the latter has strong implications for neural diseases:

"Identifying and targeting abnormal mitochondrial localization associated with psychoses", Haghighi et al. 2025 (Anne Carpenter's lab).
biorxiv.org/content/10.1101/20…

Interestingly, mitochondrial mislocalization within the cell occurs not just in neurons but in all cells, hence this study focused on skin cells (!). Much easier to sample and study.

#neuroscience #mitochondria #NeuralDisease