Neurons and particularly their synapses are so dependent on ATP produced by mitochondria that the mislocalization of the latter has strong implications for neural diseases:

"Identifying and targeting abnormal mitochondrial localization associated with psychoses", Haghighi et al. 2025 (Anne Carpenter's lab).
biorxiv.org/content/10.1101/20…

Interestingly, mitochondrial mislocalization within the cell occurs not just in neurons but in all cells, hence this study focused on skin cells (!). Much easier to sample and study.

#neuroscience #mitochondria #NeuralDisease

New #ISEPpapers #preprint! Comprehensive analysis of the microbial consortium in the culture of flagellate #Monocercomonoides exilis biorxiv.org/content/10.1101/20… #protists #microbes #mitochondria #bacteria #biorxiv @biorxivpreprint

"Monocercomonoides exilis is the only known amitochondriate eukaryote, making it an excellent model for studying the implications of mitochondrial reduction from a cellular and evolutionary point of view."

Single-celled #protists in the #guts of #animals thrive without #mitochondria, study finds.

#oxymonads #evolution #phylogenomics

phys.org/news/2023-12-single-c…

Single-celled protists in the guts of animals thrive without mitochondria, study finds

Almost all eukaryotic organisms, from plants and animals to fungi, can't survive without mitochondria, which generate chemical energy using oxygen.

^{Science X (Phys.org)}

Highlight: Unlocking the Ancient Origins of Cell Death

doi.org/10.1093/gbe/evad172

"They propose that early protoeukaryotes were predators, relying on bacterial prey. These bacteria, in response to predation, produced toxins as a defense mechanism. Over time, these bacteria were domesticated to serve as mitochondria within eukaryotic cells, and their toxins evolved into apoptotic factors. "

#evolution #eukaryotes #apoptosis #mitochondria

High school didn't teach you how to do your taxes, how to negotiate pay, or the value of creativity, but I bet all of you learned that THE MITOCHONDRIA IS THE POWERHOUSE OF THE CELL.

Let's talk about what you SHOULD have learned about the #mitochondria.