Neurons and particularly their synapses are so dependent on ATP produced by mitochondria that the mislocalization of the latter has strong implications for neural diseases:

"Identifying and targeting abnormal mitochondrial localization associated with psychoses", Haghighi et al. 2025 (Anne Carpenter's lab).
biorxiv.org/content/10.1101/20…

Interestingly, mitochondrial mislocalization within the cell occurs not just in neurons but in all cells, hence this study focused on skin cells (!). Much easier to sample and study.

#neuroscience #mitochondria #NeuralDisease

New #ISEPpapers #preprint! Comprehensive analysis of the microbial consortium in the culture of flagellate #Monocercomonoides exilis biorxiv.org/content/10.1101/20… #protists #microbes #mitochondria #bacteria #biorxiv @biorxivpreprint

"Monocercomonoides exilis is the only known amitochondriate eukaryote, making it an excellent model for studying the implications of mitochondrial reduction from a cellular and evolutionary point of view."

Single-celled #protists in the #guts of #animals thrive without #mitochondria, study finds.

#oxymonads #evolution #phylogenomics

phys.org/news/2023-12-single-c…

Highlight: Unlocking the Ancient Origins of Cell Death

doi.org/10.1093/gbe/evad172

"They propose that early protoeukaryotes were predators, relying on bacterial prey. These bacteria, in response to predation, produced toxins as a defense mechanism. Over time, these bacteria were domesticated to serve as mitochondria within eukaryotic cells, and their toxins evolved into apoptotic factors. "

#evolution #eukaryotes #apoptosis #mitochondria

High school didn't teach you how to do your taxes, how to negotiate pay, or the value of creativity, but I bet all of you learned that THE MITOCHONDRIA IS THE POWERHOUSE OF THE CELL.

Let's talk about what you SHOULD have learned about the #mitochondria.