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Items tagged with: CRISPR

Sorry I missed this symposium at the #Denver #AAASmtg. If there’s interest, I can send the transcript of a similar event during the 2019 #Tennessee #STEAM Festival; “From Plato to #CRISPR : Communicating #Science through Story-telling.” #STEAMfest #SciComm

https://www.codrescu.com/happeningsappearances-1/2019/10/16/from-plato-to-crispr-communicating-science-through-storytelling


From Plato to CRISPR: Communicating Science through Storytelling — Andrei Codrescu

Third Annual Tennessee STEAM Festival @Middle Tennessee University Through his talk, From Plato to CRISPR , Andrei brings light and heat to the space between science and art
Andrei Codrescu
#science #Steam #scicomm #crispr #tennessee #denver #aaasmtg #steamfest

#Bacteriophages encode anti-CRISPR proteins that inactivate bacterial #CRISPR-Cas systems, allowing successful invasion, replication & integration. This study shows that #antiCRISPR protein AcrIIA1 induces degradation of #Cas9 in human cells #PLOSBiology https://plos.io/3uUGAos

Cas9 degradation in human cells using phage anti-CRISPR proteins

Bacteriophages encode anti-CRISPR proteins that inactivate CRISPR-Cas bacterial immune systems, allowing successful invasion, replication, and prophage integration.
plos.io
#plosbiology #crispr #bacteriophages #cas9 #anticrispr

A diverse set of species, from #snails to #algae to #amoebas, make programmable DNA-cutting enzymes called #Fanzors — and a new study from scientists at MIT’s McGovern Institute for Brain Research has identified thousands of them.
#CRISPR #DNA #RNA #Microbiology #sflorg
https://www.sflorg.com/2023/10/mcb10142302.html

Thousands of programmable DNA-cutters found in algae, snails, and other organisms

New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.
www.sflorg.com
#microbiology #crispr #amoebas #RNA #algae #sflorg #dna #snails #fanzors

#Rotifers have been studied for >100 years re #microevolution, #EcologicalDynamics & #ecotoxicology. This study presents a #CRISPR-based method for KO mutation of 1 or 2 alleles, and KI mutations, in rotifers with high efficiency @MBLscience #PLOSBiology https://plos.io/3Kb8CAC

Highly efficient CRISPR-mediated gene editing in a rotifer

Rotifers have been studied in the laboratory and field for over 100 years in investigations of microevolution, ecological dynamics and ecotoxicology.
plos.io
#plosbiology #crispr #ecotoxicology #ecologicaldynamics #microevolution #rotifers

Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy
https://www.nature.com/articles/s41564-022-01318-2
#phage #bacteria #crispr

Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy - Nature Microbiology

Deployment of some CRISPR-Cas systems stunts host growth by degrading all transcripts, but Listeria seeligeri reverses dormancy using restriction-modification-based phage DNA targeting.
Nature
#bacteria #crispr #phage

#phage + #Eggerthella + #CRISPR + mice + #gut = 👇

https://www.nature.com/articles/s41396-023-01358-4

Congrats to all !

CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice - The ISME Journal

The ISME Journal - CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice
Nature
#crispr #phage #eggerthella #gut

Many in vitro #CRISPR knock-in approaches use small molecule drugs to improve the efficiency of homology-directed repair, but these drugs may or may not be safe in vivo. In this paper from #NatureBiotechnology, the authors find that an FDA-approved therapy, fludarabine, can be used for a similar purpose. Still a long ways to go before any genetic knock-ins are routinely done in vivo, but making progress toward doing so safely: https://www.nature.com/articles/s41587-022-01240-2 #science #medicine #GeneEditing #AAV

Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice - Nature Biotechnology

Fludarabine-induced DNA damage pathways enhance the in vivo efficiency of homologous recombination-based gene editing.
Nature
#science #medicine #AAV #geneediting #naturebiotechnology #crispr

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