Our new preprint on the impact of protein phosphorylation on structures is now out!

Protein phosphorylation is a key regulator of cellular processes.It's ubiquitous, yet the function and relevance of most phosphosites is unknown. Understanding phosphosite function requires elucidating the structural mechanisms through which it acts. (1)

https://www.biorxiv.org/content/10.1101/2024.10.18.617420v1?med=mas

@bioinformatics @strucbio #bioinformatics #protein #StructuralBiology

Global comparative structural analysis of responses to protein phosphorylation

Post-translational modifications (PTMs), particularly protein phosphorylation, are key regulators of cellular processes, impacting numerous aspects of protein activity.

^bioRxiv

Elizabeth Villa's lab delivers big time again with in-cell cryo-electron tomography of the nuclear pore complex:

"The molecular architecture of the nuclear basket" by Singh et al. 2024.
https://www.cell.com/cell/fulltext/S0092-8674(24)00780-3

#CellBiology #CryoEM #ProteinStructure #StructuralBiology

Alphafold 3 server has dropped, kids. https://golgi.sandbox.google.com/about

Can do select small mols, PTMs, Nucleic acids and ions.

#StructuralBiology @strucbio #Science #Research #Crystallography #CryoEM #NMR

🎨 🧬 Take a look at the extraordinary watercolor paintings in the Molecular Landscapes Gallery by David S. Goodsell.

The watercolor paintings of David S. Goodsell integrate information from #StructuralBiology, #Microscopy and #Biophysics to simulate detailed views of the molecular structure of living cells. #Proteins, #NucleicAcids, and #LipidMembranes are shown; #SmallMolecules, ions, and water are omitted for clarity.

https://pdb101.rcsb.org/sci-art/goodsell-gallery/

Free for use under CC-BY-4.0 license.

PDB101: Goodsell Gallery

PDB-101: Training, Outreach, and Education portal of RCSB PDB

^{RCSB: PDB-101}