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Items tagged with: immunology
https://www.nature.com/articles/d41586-023-03364-0?utm_medium=Social#ref-CR3
Viral infection triggers the production of cyclic GMP–AMP synthase (cGAS), an enzyme that synthesizes cyclic GMP–AMP (cGAMP) to activate the downstream effector response.
https://www.science.org/doi/epdf/10.1126/science.1232458
A viral RNA molecule activates the bacterial immune system during infection
A bacterial defence system against bacteriophage infection recognizes a specific structured viral RNA to start producing cyclic nucleotides for immune signalling.www.nature.com
IL-6 is such a fascinating cytokine.
Here it is modulating different dendritic cell subsets
@JExpMed
#immunology #DC #cytokine #science
https://rupress.org/jem/article/220/10/e20221757/214227/IL-6-selectively-suppresses-cDC1-specification-via?guestAccessKey=48cccc06-d788-423c-889f-51498d95a918&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2ph4e3-co3ru7-cwe4ixj2
IL-6 selectively suppresses cDC1 specification via C/EBPβ
We show that tumor-derived IL-6 blocks the development of type 1 classical dendritic cells through the induction of C/EBPβ in the common dendritic cell progenitKim, Sunkyung (Rockefeller University Press)
The 'There Are Such Things As Cooties' book doesn't appear to be available in UK.
I have a serious need to know as osculation, for me, has always carried great risk, #autoimmunesystem highly compromised.
The first few months of a new romantic relationship is fraught with a horrid cascade of immune response symptoms. And yet, I still do it!!! It's a really difficult one to resist.
#science #biology #immunology #immunesystem
My first post on Mastodon after a whole lot of lurking and boosting, so I'm treating this as a mini #introduction for myself
I'm an #immunology PhD candidate at #ColumbiaUniversity medical center, and we just published a study of #TissueSpecifity of human #Tcell identity and clonal expansion in barrier sites, using #CyTOF, #scRNAseq, and #TCR #sequencing!
https://www.nature.com/articles/s41590-022-01395-9
Tissue adaptation and clonal segregation of human memory T cells in barrier sites - Nature Immunology
Farber and colleagues examine the phenotypic, transcriptomic, clonal, and functional differences between tissue-resident T cells in various barrier tissue sites relative to T cells in lymphoid organs and circulation in humans.Nature
'To address this critical knowledge gap, we conducted a comprehensive cross-species analysis of transcriptomic data from over 6000 blood samples from macaques and humans infected with one of 31 viruses, including #Lassa, #Ebola, #Marburg, #Zika, and #dengue.'
#Immunology #Virology #preprint
https://www.biorxiv.org/content/10.1101/2023.06.22.546003v1?med=mas
Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans
Viral pandemics and epidemics pose a significant global threat, with emerging and re-emerging viruses responsible for four pandemics in the 21st century alone.bioRxiv
Bioinformatician with PhD and experience in immunology and single-cell
Institut Curie
Looking for a #bioinformatician with a PhD, experience in #immunology and #single-cell. Come join us at #InstitutCurie in #Paris
See the full job description on jobRxiv: https://jobrxiv.org/job/institut-curie-27778-bioinformatician-with-phd-and-experience-in-immunology-and-si...
https://jobrxiv.org/job/institut-curie-27778-bioinformatician-with-phd-and-experience-in-immunology-and-single-cell/?feed_id=47187
Science Jobs - Find science and research jobs
The international job board for scientists, by scientists. Find science jobs in academia or industry: MSc, PhD, Postdoc, Scientist, Faculty and more!Paul (jobRxiv)
Immunology Lecturer in the Department of Microbiology at the University of Tennessee-Knoxville
http://apply.interfolio.com/123857
#immunology #academicjobs
#immunology #InnateImmunity
"We demonstrate that MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c) is a mitochondrial-encoded amphipathic and cationic peptide with direct antibacterial and immunomodulatory functions, consistent with the peptide chemistry and functions of known HDPs."
https://www.biorxiv.org/content/10.1101/2023.03.02.530691v1
The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide
The mitochondrial DNA (mtDNA) can trigger immune responses and directly entrap pathogens, but it is not known to encode for active immune factors. The immune system is traditionally thought to be exclusively nuclear-encoded.bioRxiv
#Virology #AlzheimersDisease #NeuroDegeneration #Neuroscience #Immunology
https://www.nature.com/articles/d41586-023-00181-3
Massive health-record review links viral illnesses to brain disease
Study ties common viruses such as flu to Alzheimer’s and other conditions — but the analysis has limitations, researchers warn.Kozlov, Max
https://www.biorxiv.org/content/10.1101/2022.12.31.521782v2
It makes so much sense to me that differentiation pathways in T cells(and biological processes i general) are much more flexible than currently depicted in literature! Why would a cell be fully stuck in one state with no way to return? HIgh time for studies like this to correct our current view on #immunology #memory #T cell #differentiation #gene regulation. So i look forward to read it!
Flexible and scalable control of T cell memory by a reversible epigenetic switch
The immune system encodes information about the severity of a pathogenic threat in the quantity and type of memory cell populations formed in response.bioRxiv