Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice - Nature Biotechnology
Fludarabine-induced DNA damage pathways enhance the in vivo efficiency of homologous recombination-based gene editing.Nature
In this paper I argue that developments in STEM education research can be accelerated through the strategic use of systematic reviews, with a particular focus on #OpenScience practices and associated benefits. DM or email if you experience acces issues.
#edutoot #education #eduresearch @OtwartaNauka @openscience @edutooters
tandfonline.com/doi/pdf/10.108…
Okay y'all, my notifications are totally blowing up. The Union Place is officially ready to get started. There's still some dust and I may have to futz with scaling, but it should be good to start receiving users!
union.place - registration is currently wide open, I will probably require approval in the not-too-distant future but I'm willing to try open to get started.
The Union Place
The Union Place: a federated server for union members, friends, and allies. If you support labor and labor rights, you have a place here!Mastodon hosted on union.place
A reminder for fellow #Australians that FrogID Week started today!
Find frogs, record them with the FrogID app and submit them as part of this wonderful #CitizenScience project.
Nextcloud is the ultimate open source productivity suite 🚀
With Nextcloud, you can replace many of the online apps you use for collaboration, organization, and task management. Read on!
opensource.com/article/21/1/ne…
How Nextcloud is the ultimate open source productivity suite
In prior years, this annual series covered individual apps. This year, we are looking at all-in-one solutions in addition to strategies to help in 2021.opensource.com
We very rarely get junk mail and so I took a quick peek at this one that turned up today.
AustPost, you may have heard if them, they’re the ones that sometimes deliver mail and parcels, are selling guitars.
Bit of a logical leap there, but there you have it.
Got my first sale on redbubble 😃
also take is a reminder that I sell on redbubble: esmailelbob.redbubble.com
Esmail EL BoB Shop | Redbubble
Esmail EL BoB is an independent artist creating amazing designs for great products such as t-shirts, stickers, posters, and phone cases.Redbubble
RT @jonquilynhill@twitter.com
"The Verge reached out to Musk for comment. Twitter no longer has a communications department." theverge.com/2022/11/10/234511…
🐦🔗: twitter.com/jonquilynhill/stat…
Twitter lawyer warns that Elon Musk is putting company at risk of billions in FTC fines
Twitter’s chief privacy officer, chief compliance officer, and chief information security officer have all stepped down.Alex Heath (The Verge)
#multitasking #hustle #grindset
like this
【TWEWY】Is Our Journey Finally Ending
Tip: https://streamlabs.com/brodierobertsonplaysPaypal: https://www.paypal.com/paypalme/BrodieRobertsonVideoPatreon: https://www.patreon.com/brodierobertsonT...YouTube
Arch Linux Finally Ships OpenSSL 3: Chaos Ensues
Finally Arch Linux started shipping OpenSSL 3.0 but by doing so it lead to tons of AUR packages especially but even packages in 3rd party repos suddenly brea...YouTube
Lately it has been "Arch does something: Chaos ensues". They really need to improve their communication.
Arch is no longer just used by just hardcore #Linux users.
You've been on the ball lately, so my update process usually starts by hearing about some issue from you, and builds on whatever observations you make.
I agree it's a little odd how slow or irregular some organisations are in maintaining their news feeds. Seems there is an infection in parts of the FOSS space of the corporate mentality that saying literally anything constitutes a legally binding promise, and so some maintainers are afraid to keep their users in the loop.
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Right, time for a proper re #introduction post since we're now on indiepocalypse.social. Boosts very welcome!
We're Exilian, and we're a democratic, volunteer-run community of creative geekery. We've existed at the exilian.co.uk website and forums since 2008: we support our members and the public more generally in indie and hobbyist creative or academic projects, wherever they are in the world.
To that end, we run the forum, publish articles about random interesting bits of information, host virtual meetups and events, run competitions and writing projects, and more besides. Our projects cover indie gamedev, writing, tabletop games, game modding, independent music and drama, and other eclectic oddments. We're excited to be here & would love to talk about the cool things you're making!
A short thread will follow of a few of the sorts of things we've done and supported, to give you a flavour 😀
#introductions #newhere #creativetoots #ttrpg #writingcommunity #gamedev
like this
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Mimetic architecture: Why does this building look like a fish?
The typical government office is unremarkable and nondescript, its purpose unknown to the outside world. Not so with the National Fisheries Development Board (NFDB) in Hyderabad, India.Cathy Adams, CNN (CNN)
like this
like this
youtu.be/1z0jfP2gCIs
The Beginner | John Lewis & Partners | Christmas Ad 2022
It’s the things we do that mean the most. 🛹 #TheBeginnerFind out more about our Building Happier Futures programme: https://www.johnlewis.com/content/happie...YouTube
like this
Okay, so. My dorky #DevSecOps-learning ass wants to run Dependency-Track (dependencytrack.org/), but it specifically checks whether it can allocate 4GB of RAM on startup and dies if it can't. I've run out of pi 4s at home and yikes, I do not want to pay for a VPS with that much memory for playing with a single utility.
...so how can I fake out the Java/docker setup to get it to run under a different amount of memory? I don't care if it's slow. Can I... use disk swap or something? 🧐
Dependency-Track | Software Bill of Materials (SBOM) Analysis
Dependency-Track is an intelligent Component Analysis platform that allows organizations to identify and reduce risk in the software supply chain. Dependency-Track is open-source and distributed under the Apache 2.0 license.dependencytrack.org
A shoutout for John Hassink who just dropped an excellent MSX+FM (AY-3-8910+YM2413) arrange of the Chrono Chross theme. He gets some very good sounding instruments out of some rather limited hardware:
youtube.com/watch?v=EpnvEKTMrA…
Chrono Cross / クロノ・クロス - Intro Music on 8-bit MSX FM
Square/Enix, 1999Composed by Yasunori Mitsuda (光田 康典)Arranged by John HassinkBig thanks go to Huey, Wyrdwad, Inverse Phase and Wolf.YouTube
Here's my (relatively) portable #famicom (#nes) #chiptune setup.
I can power it with a portable USB battery and it packs away easily into a small bag. Great way to get my #2A03, #MIDINES fix on the go!
For other #chipmusic folks, what's your favourite (relatively) portable setup?
For other #micromusic or #electronicmusic people, what about you all?
The only paid one I have is sinevibes.com/korgodds/ And it's really powerful.
Proba-B by Tweeeeeak is similar in a way, and pretty cool too. github.com/tweeeeeak/nts
There's also a pluck one, and of course, a bunch of FX (an autopan, some good reverb). I really don't remember the name of most of them, but I can make a list of my favorite this week-end if you're interested!
Yeah, I have to say that I have been unable to code anything for it.
GitHub - tweeeeeak/nts: NTS oscillators and stuff
NTS oscillators and stuff. Contribute to tweeeeeak/nts development by creating an account on GitHub.GitHub
There's so much micro-aggressions on here against black people. The thing with micro-aggressions is that it quickly piles up.
Mastodon culture, yes still on the "nice side", whatever that means, suffers from this still.
Any time you deny that there's anti-blackness on here, it's because you just aren't equipped to see it. Heck I'm not equipped to see it yet. So I'm going to defer to someone else.
reshared this
Musk might have screwed himself over royally with yesterday's new feature stunt: techdirt.com/2022/11/10/does-t….
Remember, the FTC doesn't play around. Even Facebook couldn't avoid a $5 billion fine. Even an Uber exec couldn't avoid federal criminal charges. This isn't the SEC we're talking about.
Does Twitter Have Any Employees Left Who Remember That The Company Is Under A Strict Consent Decree With The FTC?
Yesterday I tweeted out a question about whether or not there was anyone left at Twitter who remembered that the company was under a pretty strict FTC consent decree: Apparently the answer was yes,…Techdirt
🧵 Reading Pape’s American Face of Insurrection, I noticed some new-to-me data about the insurrectionists of Jan 6, especially concerning grievances.
d3qi0qp55mx5f5.cloudfront.net/… #sociology #collectivebehavior
welcome to the fediverse! 👋
when you post threads could you please set the toots following the first as unlisted so they don't take up excessive space on the local timeline. It also helps read a thread as the expanded view will display toots from oldest to newest versus the timeline which lists them newest to oldest
excited to see what conversations you may spark in the local timeline 😁
Want to follow what happens in Nextcloud? Subscribe to our Newsletter and receive updates! 💙
newsletter.nextcloud.com/?p=su…
I can't wait, I CAN'T WAIT
John Wick Chapter 4 - Official Trailer (2023) Keanu Reeves, Donnie Yen, Bill Skarsgård
Check out the trailer for John Wick: Chapter 4, the upcoming movie starring Keanu Reeves, Donnie Yen, Bill Skarsgård, Laurence Fishburne, Hiroyuki Sanada, Sh...YouTube
youtube.com/watch?v=uTFRS0SUds…
so, while we're still debating all this cw stuff and reminiscing about how bipoc people have been and are pushed off the fedi, please, take a moment and watch this video:
content warning for violence against minorities because I swear to the divine entity of your preference it gets the point across so violently and clearly that I honestly had to hold back tears the first time I watched it and I'm not exaggerating.
youtube.com/watch?v=oDQXFNWuZj…
yeah, it is a white guy (maybe that will make you listen I dunno) but the point is there.
before you go tone policing, before you move to somewhat silence anybody who is trying to speak, remember this.
Bo Burnham: How The World Works
Here's a happy little song about the world sung by Bo Burnham and his special friend, Socko.Bo Burnham: Inside is streaming now on Netflix.Subscribe: https:/...YouTube
if you didn't get it, the point is that being socko is just everyday for us.
most of the time we don't have our own voice because we'll not get listened to. the white people need to be willing to listen or to give us platforms and everytime they do if we don't choose carefully what we say we upset the white people and they may react violently in a way that is just plain accepted by everyone around us.
the angry black person stereotype is a testament of this. it is what happens when we're not willing to play by the rules white people set for us.
"oh please, explain to me this upsetting subject that I could go and learn myself" says the white people and when we get upset by the subject or by having to explain that to then they get violent.
do you have any fucking idea how taxing living like this is? how much energy goes into that?
that is how the word fucking works :')
hello there, welcome to the fediverse 👋 I too am feeling pressure of the 3 raptor... I mean viruses.
I'd like to let you know that folks on the fediverse try to add alt text to their images. If you could delete and re-draft that would be great. I follow @PleaseCaption for reminders. I think it's a really good habit to get into that helps folks with screen readers access your content (and sometimes is a part of the humor) as well some folks (me included) won't boost without alt text.
Michael Tunnell : The Open Sourcerer @MichaelTunnell@twitter.com
I sat down with Mark Shuttleworth, Founder and CEO of @Canonical@twitter.com for an in-depth interview about @ubuntu@twitter.com, the #UbuntuSummit, and his experiences. We will be releasing this interview soon!
JMWillustration
The portfolio of Jabari Weathers, illustrator. Here, amongst other things you may find images of the strange, and if you venture deep enough, the beautiful as well.Bolton Hill
Open Science ✅
in reply to Alex Silver • • •