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Items tagged with: Bioinformatics


I wanted to share with you a new thing I'm working on: https://biohandbook.me/

It's a resource for practical best practices and tips to use in bioinformatic analyses. The idea is to work together to define standards and workflows and write them down. I love the open science, FAIR data and FAIR code philosophy but there are not many easy-to-use and direct resources around to actually tell you how to do things in the bioinformatics world.

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#bioinformatics #handbook #OpenScience


So many good points in this piece by
@PhilippBayer

My highlight in this screenshot (#science delivery & success is a TEAM effort!), but if you're vaguely involved in #academia +/- #bioinformatics, do have a read and think how it all may apply to you. #academicchatter @academicchatter
https://genomic.social/@PhilippBayer/110644840476993836


A new blog-post: the two cultures of bioinformatics, and how academia selects against one https://philippbayer.github.io/blerg/posts/2023_07_02_the_two_cultures/


#introduction
Hello everyone!
I’m an associate prof at Virginia Tech studying viral diversity. Lately my group has been focusing on giant viruses, but we are also interested in other protist viruses, and the role of viral endogenization in host genome evolution.
#GiantViruses #ViralDiversity #TreeOfLife #Protists #Microbiology #Bioinformatics #Evolution #Virology #Genomics
Recently we have been examining the strange and complex genes encoded in giant virus genomes!
https://doi.org/10.1093/femsre/fuad053


Studying some phage genes with scattered, partial alignments in varying degrees (40~+90%) of ID against closely related cousins (~93% ANI).

I'm thinking intragenic insertion/shuffling - but what kind of signals could I look for here? Common scars? Models to reference? #phage #bioinformatics #genomics


Looks interesting, Heng Li proposes a faster #BUSCO: "miniBUSCO achieves a 14-fold speedup over BUSCO. Furthermore, miniBUSCO reports a more accurate completeness of 99.6% than BUSCO’s completeness of 95.7%, which is in close agreement with the annotation completeness of 99.5% for T2T-CHM13"
https://www.biorxiv.org/content/10.1101/2023.06.03.543588v1 #bioinformatics #HumanGenome #genomics


Accounting for 16S rRNA copy number prediction uncertainty and its implications in bacterial diversity analyses

https://www.nature.com/articles/s43705-023-00266-0

#microbiology #bioinformatics #microbiome


Distribution and diversity of ‘Tectomicrobia’, a deep-branching uncultivated bacterial lineage harboring rich producers of bioactive metabolites
https://doi.org/10.1038/s43705-023-00259-z
#microbiology #bioinformatics


A review of 324 common R packages for microbiome analysis https://academic.oup.com/proteincell/advance-article/doi/10.1093/procel/pwad024/7147618 #microbiome #rstats #bioinformatics


Every base everywhere all at once: pangenomics comes of age

https://www.nature.com/articles/d41586-023-01300-w

#genomics #bioinformatics


JASPER: A fast genome polishing tool that improves accuracy of genome assemblies

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011032

#genomics #bioinformatics


The methanogen core and pangenome: conservation and variability across biology’s growth temperature extremes https://doi.org/10.1093/dnares/dsac048 #microbiology #bioinformatics


A field-wide assessment of differential expression profiling by high-throughput sequencing reveals widespread bias https://doi.org/10.1371/journal.pbio.3002007 #microbiology #bioinformatics


From @PLOS #ComputationalBiology | An overview of #bioinformatics courses delivered at the academic level in #Italy: Reflections and recommendations from BITS | #Education | Bioinformatics Italian Society (BITS) | https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1010846


Pathogen detection in RNA-seq data with Pathonoia

https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-023-05144-z

#bioinformatics #pathogens #viruses


New preprint, by Victor Rossier with the group of Christophe Dessimoz (#UNIL and #SIB), introducing #Matreex, a new dynamic tool to scale-up the visualisation of gene families, and its application to showing loss of intraflagellar transport in a myxozoan
https://www.biorxiv.org/content/10.1101/2023.02.18.529053v1
#phylogeny #phylogenomics #bioinformatics #BigData #visualization #vizbi #myxozoan @dee_unil
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High-resolution metagenomic reconstruction of the freshwater spring bloom https://doi.org/10.1186/s40168-022-01451-4 #microbiology #bioinformatics


We are looking for a Bioinformatician! The focus of the work will be on the development, application and validation of novel approaches and workflows in the area of long-read sequencing, which was recently awarded as Nature Method of the year 2022. https://www.mpi-cbg.de/join-us/open-positions/job-offer/bioinformatician-postdoc-m-f-d #mpicbg #postdoc #postdocposition #bioinformatics


If you've ever wondered EXACTLY what is in
@NCBI
nt and nr (I certainly have!)

From https://youtu.be/2FW1dk5YQ3I?t=484 and https://youtu.be/KLBE0AuH-Sk?t=692 (cued to the right spots in the video)

#Bioinformatics #Genomics


When I started my lab a few years ago I started building up an in-house library for students. Two of the first books I bought are The Logic of Chance (Eugene Koonin) and The Origins of Genome Architecture (Michael Lynch). Both are remarkable books that discuss genomics in the context of microbial diversity and the tree of life.

What other genomics/evolution classics do people always keep around?

#genomics #bioinformatics #evolution #microbiology

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