I'm extracting DNA from the legs of spiders which were euthanized by freezing in a household freezer. In almost every spider, the DNA shows a banding pattern associated with apoptosis. Why would there be so much programed cell death in the legs of spiders? Had it already happened naturally? Was it induced during the freezing process? I do not see this happening in other organisms using the same extraction procedure.

Each lane is DNA extracted from a different spider.

#genetics #DNA #apoptosis

PhD studentship to characterise aphid immune evolution. Lots to uncover in an insect group with major ecological & economic impact. Aphid systemic immunity is a black box. The interested PhD candidate will both provide one of the first detailed descriptions of aphid immunity, but also uncover principles of immune evolution.

Deadline July 29th at #UoExeter
Email or DM for details🐘 📩
m.hanson@exeter.ac.uk

#Genomics #Aphid #Genetics #Immunity #Evolution #Drosophila

Gotta check these out!

Robust, scalable, and informative clustering for diverse biological networks

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03062-0

#bioinformatics #genomics #genetics #statistics

Robust, scalable, and informative clustering for diverse biological networks - Genome Biology

Clustering molecular data into informative groups is a primary step in extracting robust conclusions from big data.

^{BioMed Central}

Come work with us! I have a PhD position available to help understand which mutations in the non-coding parts of coding transcripts have functional consequences in Stem Cells.

We will using genome wide mesaurement of the effect of variation in miRNA binding sites to address when vairation causes changes in regulation and when it doesn't.

Mixed wetlab, bioinformatics and statistics project.

https://www.findaphd.com/phds/project/white-rose-bbsrc-dtp-how-can-we-identify-variants-in-untranslated-rna-that-affect-stem-cells/?p160958

#phdPosition #PhD #bioinformatics #UTR #miRNA #genetics

White Rose BBSRC DTP: How can we identify variants in untranslated RNA that affect stem-cells at University of Sheffield on FindAPhD.com

PhD Project - White Rose BBSRC DTP: How can we identify variants in untranslated RNA that affect stem-cells at University of Sheffield, listed on FindAPhD.com

^{www.FindAPhD.com}

Seeking applicants for #PhD projects on #genetics & #language:

1) Deciphering roles of rare genetic variants in developmental speech/language disorders. This project studies impacts of pathogenic gene disruptions by integrating data from clinical & speech/language profiles of affected patients with lab-based analyses in human neuronal models (e.g. brain organoids).

2) Mapping language-relevant genetic effects on brain variability using normative modelling. Here, we apply normative modelling to large-scale imaging & DNA data from the general population, to uncover heterogeneous effects of language-relevant genetic variants.

3) Genetic architecture of the human language network. In this project, we employ advanced neuroimaging techniques to map neural circuits involved in language processing, characterize interindividual differences in their properties, & associate them with DNA variation in unique cohorts.

Applications due before Jan 8th 2024. More info here: https://www.mpi.nl/imprs-phd-fellowships-2024

Hey Mastodon! 👋 Here is our #introduction post: We are the Data Visualization Lab at Khoury College of Computer Sciences at Northeastern University. You can find more about our work here: https://vis.khoury.northeastern.edu/

We'd love to be connected to more folks and labs in the realms of #DataVisualization #HCI #xAI #AR #VR #VisualAnalytics #PhD #Research

Our lab has been applying visualization to domain areas like #accessibility #UAVs #Genetics #Privacy #Pedagogy #Networks #GraphTheory

Say hi!

Cool paper! Also glad we are moving towards Patescibacteria and not CPR:

"Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle"

https://doi.org/10.1016/j.cell.2023.08.017

#microbiology #genomics #genetics