Search
Items tagged with: viruses
Happy to share a collaborative preprint with Assaf Vardi's group in which we use single cell transcriptomics to link giant viruses with their native hosts during a marine algal bloom!
This approach is quite sensitive - we were able to identify viruses infecting one protist group that made up <0.5% of the community.
Homing in on the rare virosphere reveals the native host of giant viruses
https://www.biorxiv.org/content/10.1101/2023.06.27.546645v1
#viruses #giantViruses #ocean #marine
Homing in on the rare virosphere reveals the native host of giant viruses
Giant viruses (phylum Nucleocytoviricota) are globally distributed in aquatic ecosystems They play major roles as evolutionary drivers of eukaryotic plankton and regulators of global biogeochemical cycles.bioRxiv
It's been a big mystery why giant viruses encode so many proteins involved in vesicular transport and cytoskeletal dynamics. This interesting paper examined a dynamin homolog and found evidence that it's involved in mitochondrial membrane remodelling during infection.
A Novel Group of Dynamin-Related Proteins Shared by Eukaryotes and Giant Viruses Is Able to Remodel Mitochondria From Within the Matrix
https://academic.oup.com/mbe/article/40/6/msad134/7190697?login=false
#viruses #GiantViruses #virology
A Novel Group of Dynamin-Related Proteins Shared by Eukaryotes and Giant Viruses Is Able to Remodel Mitochondria From Within the Matrix
Abstract. The diverse GTPases of the dynamin superfamily play various roles in the cell, as exemplified by the dynamin-related proteins (DRPs) Mgm1 and Opa1, whSheikh, Shaghayegh (Oxford University Press)
Referenced link: https://phys.org/news/2023-06-viruses-sea-lice-bay-wild.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-06-viruses-sea-lice-bay-wild.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1671941139862093824#m
Are #viruses keeping #sealice at bay in wild salmon? @ubcnews @PLOSPathogens https://phys.org/news/2023-06-viruses-sea-lice-bay-wild.html
Are viruses keeping sea lice at bay in wild salmon?
More than 30 previously unknown RNA viruses in sea lice have been identified by University of British Columbia (UBC) researchers.Science X (Phys.org)
Built Into the Genome of the Microbes – Scientists Uncover Over 30,000 “Hidden” Viruses
Built Into the Genome of the Microbes – Scientists Uncover Over 30,000 “Hidden” Viruses
Unveiled within the DNA of unicellular organisms lie thousands of enigmatic viruses. Researchers at the University of Innsbruck, utilizing the high-performance computing cluster known as "Leo," have identified more than 30,000 new viruses embedded wi…Colin Collins (SciTechDaily)
It was wonderful to speak with Vincent Racaniello during the Aquatic Virus Workshop in Quebec last week! Fun conversation.
#viruses #ecology #evolution #virology
TWiV 1011: Aquatic viruses
Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Frank Aylward and Jed Furman about the research of their lab...YouTube
'#Bioprospecting' technique uncovers #viruses that can kill deadly superbugs.
#phages #antimicrobial #epitopes #porin
https://phys.org/news/2023-05-bioprospecting-technique-uncovers-viruses-deadly.html
'Bioprospecting' technique uncovers viruses that can kill deadly superbugs
In a modern take on the Victorian gold rush, a Monash University-led project is successfully "bioprospecting" for viruses known as phages that can kill deadly superbugs.Cheryl Critchley (Phys.org)
https://plos.io/3M9uUTH
Beyond pathogenesis: Detecting the full spectrum of ecological interactions in the virosphere
Viral interactions with their hosts are complex and can be beneficial, yet the public perception of viruses is generally negative.plos.io
Beyond pathogenesis: Detecting the full spectrum of ecological interactions in the virosphere
"Viral interactions with their hosts are complex and some non-pathogenic viruses could have potential benefits to society. However, viral research is seldom designed to identify viral mutualists, a gap that merits considering new experimental designs."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002109
#viruses #pathogens #symbiosis
Beyond pathogenesis: Detecting the full spectrum of ecological interactions in the virosphere
Viral interactions with their hosts are complex and can be beneficial, yet the public perception of viruses is generally negative.journals.plos.org
Important study from Bellas et al showing that protists have a huge diversity of endogenous DNA viruses in their genomes!
Large-scale invasion of unicellular eukaryotic genomes by integrating DNA viruses
https://www.pnas.org/doi/10.1073/pnas.2300465120
And a commentary about these exciting findings from @giant_virus and myself -
Endogenous DNA viruses take center stage in eukaryotic genome evolution
Viral infections likely mediate microbial controls on ecosystem responses to global warming
https://academic.oup.com/femsec/article/99/3/fiad016/7057867
Viral infections likely mediate microbial controls on ecosystem responses to global warming
We provide a roadmap for understanding how viral infections within microbial food webs may mediate the effects of global warming on ecosystem carbon and nutrienWieczynski, Daniel J (Oxford University Press)
Hijacking strategy mapped for hundreds of #viruses.
#infection #protein #motif #phages
https://phys.org/news/2023-05-hijacking-strategy-hundreds-viruses.html
Hijacking strategy mapped for hundreds of viruses
One strategy that viruses use to take over a host cell is to mimic small parts of the cell's proteins called motifs.Science X (Phys.org)
Our latest work on marine giant virus diversity -
Assessing the biogeography of marine giant viruses in four oceanic transects
https://www.nature.com/articles/s43705-023-00252-6
#viruses #marine #ocean #giantviruses
Assessing the biogeography of marine giant viruses in four oceanic transects - ISME Communications
ISME Communications - Assessing the biogeography of marine giant viruses in four oceanic transectsNature
Cheating leads to the evolution of multipartite viruses
In multipartite viruses, the genome is split into multiple segments, each of which is transmitted via a separate capsid.plos.io
https://www.nature.com/articles/s41396-023-01414-z
#phages #viruses #transposons
Unexplored diversity and ecological functions of transposable phages - The ISME Journal
The ISME Journal - Unexplored diversity and ecological functions of transposable phagesNature
Mirusviruses link herpesviruses to giant viruses
https://www.nature.com/articles/s41586-023-05962-4
I was honored to be asked to review this paper! Wonderful work.
#virology #viruses #herpesviruses #giantViruses
Mirusviruses link herpesviruses to giant viruses - Nature
A phylogeny-guided genome-resolved metagenomic analysis of DNA viruses in the ocean reveals atypical plankton-infecting relatives of herpesviruses that form a putative new phylum dubbed Mirusviricota.Nature
"The viral inner membrane-integrated anchor protein colocalizes with the endoplasmic reticulum (ER), supporting the hypothesis that the biogenesis of the inner membrane is associated with the ER"
Nice confirmation about where the viral inner membrane comes from.
https://www.nature.com/articles/s41467-023-37681-9
#viruses #giantViruses #virology
Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly - Nature Communications
High morbidity and mortality in aquatic have been caused by iridovirids worldwide. Here the authors present a near-atomic SGIV capsid structure. Functional assays further reveal the relationships between identified capsid proteins and viral assembly.Nature
https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-023-01500-6
#viruses #microbiome
In-depth study of tomato and weed viromes reveals undiscovered plant virus diversity in an agroecosystem - Microbiome
Background In agroecosystems, viruses are well known to influence crop health and some cause phytosanitary and economic problems, but their diversity in non-crop plants and role outside the disease perspective is less known.BioMed Central
https://academic.oup.com/ve/advance-article/doi/10.1093/ve/vead024/7087189?rss=1
#viruses #evolution
Non-structural genes of novel lemur adenoviruses reveal codivergence of virus and host
Abstract. Adenoviruses are important human and animal pathogens, and are frequently used as vectors for gene therapy and vaccine delivery. Surprisingly, there aVeith, Talitha (Oxford University Press)
https://journals.asm.org/doi/epub/10.1128/spectrum.04944-22
#GiantViruses #Viruses #poxviruses
It doesnt mean that the virus “would turn people into zombies”. They meant “the virus has been dormant in permafrost for a long time and it has now been resurrected.”
#science #viruses #zombies
https://www.cnn.com/2023/03/08/world/permafrost-virus-risk-climate-scn/index.html
https://academic.oup.com/bioinformatics/article/39/3/btad093/7043093
#viruses #metagenomics
VirBot: an RNA viral contig detector for metagenomic data
AbstractSummary. Without relying on cultivation, metagenomic sequencing greatly accelerated the novel RNA virus detection. However, it is not trivial to accuratChen, Guowei (Oxford University Press)
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad123/7068371?rss=1
#phages #viruses #microbiology
Identification and characterization of thousands of bacteriophage satellites across bacteria
Abstract. Bacteriophage–bacteria interactions are affected by phage satellites, elements that exploit phages for transfer between bacteria. Satellites can encodde Sousa, Jorge A Moura (Oxford University Press)
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010978
#viruses #evolution
Influenza A virus coinfection dynamics are shaped by distinct virus-virus interactions within and between cells
Author summary The co-occurrence of distinct virus populations within a single host occurs commonly, when an individual acquires a second infection before a prior one has been cleared.journals.plos.org
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-023-05144-z
#bioinformatics #pathogens #viruses
Pathogen detection in RNA-seq data with Pathonoia - BMC Bioinformatics
Background Bacterial and viral infections may cause or exacerbate various human diseases and to detect microbes in tissue, one method of choice is RNA sequencing.BioMed Central
Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY
https://www.biorxiv.org/content/10.1101/2023.02.24.529968v1?rss=1
#phage #viruses
Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY
We recently discovered that some bacteriophages establish a nucleus-like replication compartment (phage nucleus), but the core genes that define nucleus-based phage replication and their phylogenetic distribution were unknown.bioRxiv
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice
https://www.nature.com/articles/s41467-023-36526-9
#phage #viruses
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice - Nature Communications
To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA.Nature
"This transcriptomics-driven characterization of LUZ100 supports recent evidence that T7-like phages should not automatically be assumed to have a strictly lytic life cycle."
https://journals.asm.org/doi/full/10.1128/msystems.01189-22?af=R
#phage #viruses
"We observed 5 viral lineages co-circulating in Nha Trang from three DENV serotypes, with two likely to have remained as uninterrupted transmission chains for a decade. This, suggests clade cryptic persistence in the area, even in during periods of low reported incidence."
https://academic.oup.com/ve/advance-article/doi/10.1093/ve/vead012/7043089?rss=1
#virology #viruses #dengue #flaviviruses
A Phylogenetic Study of Dengue Virus in Urban Vietnam shows Long-term Persistence of Endemic Strains
AbstractBackground. DENV causes repeated outbreaks of disease in endemic areas, with patterns of local transmission strongly influenced by seasonality, importatAshall, James (Oxford University Press)
"Collectively, our data support a model where suppression of quorum-regulated virulence factors by Pf4 allows P. aeruginosa to evade detection by innate host immune responses."
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010925
#viruses #virology #symbiosis #phage
Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes
Author summary Pseudomonas aeruginosa is an opportunistic bacterial pathogen that infects wounds, lungs, and medical hardware. P. aeruginosa strains are often themselves infected by a filamentous virus (phage) called Pf.journals.plos.org
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011145
#virology #viruses
https://journals.asm.org/doi/10.1128/msystems.01260-22
#viruses #giantviruses #marine
Four principles to establish a universal virus taxonomy
Transforming an existing phenotypic classification of viruses into one based on evolutionary relationships that can accommodate the vast number of viruses characterized in metagenomics and environmental studies is an ongoing challenge.plos.io
"we show that adenovirus infection leads to a reduction of the quantity and/or enzymatic activity of the APOBEC3B protein depending on the strains. The A12 strain seems less able to resist APOBEC3B than the B3 or C2 strains, a characteristic which could explain the strong depletion of the APOBEC3-targeted motifs in the A12 genome."
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011156
#viruses #virology
The APOBEC3B cytidine deaminase is an adenovirus restriction factor
Author summary The APOBEC3B protein is overexpressed in many human tumors and promotes genetic diversity and resistance to drug and oncolytic viruses.journals.plos.org
Assessing the biogeography of marine giant viruses in four oceanic transects
Viruses of the phylum Nucleocytoviricota are ubiquitous in ocean waters and play important roles in shaping the dynamics of marine ecosystems.bioRxiv
This exciting new research explores the influence of #virus #infection in changing the balance of organic matter degradation between #bacteria and #eukaryotes in #marine #carboncycling during #phytoplankton blooms.
Based on #mesocosm studies, this research demonstrates how #viruses infecting different #microorganisms change community dynamics and the release and potential fate of marine carbon from primary production.
Learn more in this new research in Nature Communications on:
https://www.nature.com/articles/s41467-023-36049-3
#microbiology #ecology #MicrobialEcology
Viral infection switches the balance between bacterial and eukaryotic recyclers of organic matter during coccolithophore blooms - Nature Communications
Algal blooms are hotspots of marine primary production that play central roles in microbial ecology and global elemental cycling.Nature
https://academic.oup.com/ve/advance-article/doi/10.1093/ve/vead008/7008731?rss=1
#viruses #virology
Phylodynamics of deer tick virus in North America
Abstract. The burden of ticks and the pathogens they carry is increasing worldwide. Powassan virus (POWV, Flaviviridae: Flavivirus), the only known North AmericMcMinn, Rebekah J (Oxford University Press)
Viral infection in the ocean—A journey across scales
"Aquatic virology tackles some of the most challenging questions in microbial ecology and oceanography, trying to understand how microorganisms that are invisible to the naked eye can influence large-scale processes, such as biogeochemical cycles, or affect entire marine food webs."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001966
#viruses #virology #ocean #marine
Viral infection in the ocean—A journey across scales
Viruses are the most abundant biological entity in the ocean. This Essay journeys across several orders of magnitude of biological organization, time, and space, to investigate interactions between hosts and viruses in the ocean and their relevance f…journals.plos.org
This is an important study that shows how #virophage have evolved multiple times independently in distinct viral groups. Turns out that #viruses infecting other viruses are quite common!
Also gotta love the opening sentence: "Eukaryotic genomes are a hub where viruses and selfish genetic elements convene" - so true.
Amazing work by the @BejaLab lab!
https://www.nature.com/articles/s41564-022-01305-7
Isolation and infection cycle of a polinton-like virus virophage in an abundant marine alga - Nature Microbiology
Isolation and characterization of a selfish genetic element with a virophage lifestyle that co-infects a bloom-forming polar algae along with a partner virus.Nature
https://plos.io/3kJcjDY
Viral infection in the ocean—A journey across scales
Viruses are the most abundant biological entity in the ocean. This Essay journeys across several orders of magnitude of biological organization, time, and space, to investigate interactions between hosts and viruses in the ocean and their relevance f…plos.io